{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:17:29Z","timestamp":1761488249508},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":5582,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1994,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>To investigate the joint association of patient and strain characteristics with the outcome of meningococcal disease (MD), data were collected on 563 consecutive cases of MD reported between 1989 and 1990 in The Netherlands. The meningococcal isolates were characterized with regard to their surface characteristics. Sequelae occurred in 8.5% of the patients, and were only associated with the presence of bacteraemia. The case-fatality rate was 7.7%. Infants aged \u2264 5 months and patients in the age-groups of 10\u201319 years and \u2265 50 years had an increased risk for a fatal outcome compared with children from 6 months to 9 years old (Odds Ratios [ORs]: 5.1, 3.4 and 9.8, respectively). The OR for females versus males was 2.3. The ORs for patients with bacteraemia, or a combination of bacteraemia and meningitis, compared with meningitic patients, were 2.3 and 3.1. Meningococcal strain characteristics did not influence the case-fatality rate substantially. In conclusion, host factors were found to be determinants for a fatal outcome of MD in The Netherlands from 1989 to 1990.<\/jats:p>","DOI":"10.1017\/s0950268800057472","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T08:56:51Z","timestamp":1242377811000},"page":"115-124","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":32,"title":["Patient and strain characteristics in relation to the outcome of meningococcal disease: a multivariate analysis"],"prefix":"10.1017","volume":"112","author":[{"given":"R. J. P. M.","family":"Scholten","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. A.","family":"Bijlmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. A.","family":"Valkenburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Dankert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,5,15]]},"reference":[{"key":"S0950268800057472_ref007","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-198901000-00003"},{"key":"S0950268800057472_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0163-4453(92)91699-C"},{"key":"S0950268800057472_ref010","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/155.2.277"},{"key":"S0950268800057472_ref016","volume-title":"The pathogenesis of infectious disease","author":"Mims","year":"1987"},{"key":"S0950268800057472_ref015","volume-title":"Applied logistic regression","author":"osmer","year":"1989"},{"key":"S0950268800057472_ref011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1987.tb02626.x"},{"key":"S0950268800057472_ref003","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400064688"},{"key":"S0950268800057472_ref001","doi-asserted-by":"publisher","DOI":"10.3109\/inf.1978.10.issue-4.04"},{"key":"S0950268800057472_ref002","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/5.1.71"},{"key":"S0950268800057472_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(84)94123-9"},{"key":"S0950268800057472_ref005","doi-asserted-by":"publisher","DOI":"10.3109\/00365548709032375"},{"key":"S0950268800057472_ref006","first-page":"861","article-title":"Association of meningococcal serogroups with the course of disease in the Netherlands. 1959\u201383","volume":"65","author":"Spanjaard","year":"1987","journal-title":"Bull WHO"},{"key":"S0950268800057472_ref009","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268800049463"},{"key":"S0950268800057472_ref012","unstructured":"Scholten RJPM. Kuipers B. Valkenburg HA. Dankert J. Zollinger WD. Poolman JT . Lipooligosaccharide immunotyping of Neisseria meningitidis by a whole-cell ELISA using monoclonal antibodies. In: Scholten RJPM . The increased incidence of meningococcal disease in the Netherlands. 1980 1990 [thesis]. Amsterdam. The Netherlands: Vrije Universiteit. 1993:45 61."},{"key":"S0950268800057472_ref013","doi-asserted-by":"publisher","DOI":"10.1093\/clind\/16.2.237"},{"key":"S0950268800057472_ref014","doi-asserted-by":"publisher","DOI":"10.1007\/BF02538460"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268800057472","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T19:28:18Z","timestamp":1557948498000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268800057472\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,2]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,2]]}},"alternative-id":["S0950268800057472"],"URL":"https:\/\/doi.org\/10.1017\/s0950268800057472","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,2]]},"assertion":[{"value":"Cambridge University Press 1994","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}