{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:52:31Z","timestamp":1771001551791,"version":"3.50.1"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":5523,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1994,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Transfer of shigella R\u2013plasmids<jats:italic>in vivo<\/jats:italic>has seldom been demonstrated. Strains of<jats:italic>Shigella dysenteriae<\/jats:italic>type 1 and<jats:italic>Shigella flexneri<\/jats:italic>type 5b were isolated from a Bulgarian traveller who visited Vietnam and developed dysentery, which was treated with trimethoprim\/sulfamethoxazole (TMP\/SMZ) for a short time. Both species of shigellae are unusual in Bulgaria where strains of<jats:italic>S. sonnei<\/jats:italic>predominate. Both shigella strains were multiresistant to the same antimicrobial agents. Each strain contained a 48\u2013kilobase plasmid that conferred the entire resistance phenotype to a susceptible<jats:italic>Escherichia coli<\/jats:italic>. Restriction endonuclease patterns of plasmid DNA from the respective strains were identical. Transmissible plasmids of the same resistance phenotypes and restriction patterns were isolated from the patient's colonic<jats:italic>E. coli<\/jats:italic>. Transconjugants hybridized to a dihydrofolate reductase type I\u2013DNA probe. These studies support the hypothesis that R\u2013plasmid transfer may occur between non-pathogenic, faecal strains and pathogenic shigellae, a process that may have been facilitated by inadequate treatment with TMP\/SMZ at the onset of the illness.<\/jats:p>","DOI":"10.1017\/s0950268800057654","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T08:48:59Z","timestamp":1242377339000},"page":"247-252","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":12,"title":["<i>In vivo<\/i>R\u2013plasmid transfer in a patient with a mixed infection of shigella dysentery"],"prefix":"10.1017","volume":"112","author":[{"given":"M. P.","family":"Bratoeva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"J. 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