{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T12:55:50Z","timestamp":1793451350399,"version":"4.5.0"},"reference-count":42,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":5158,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1995,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A prospective longitudinal survey of cutaneous leishmaniasis (<jats:italic>Leishmania peruviana<\/jats:italic>) was carried out in Peru on a study population of 4716 persons living in 38 villages (Departments of Lima, Ancash and Piura). Demographic and clinical data were collected from all individuals, and a Montenegro skin test (MST) was carried out on 72% (3418) of the study population. Each household was revisited at 3-monthly intervals for up to 2 years to detect new leishmaniasis cases; 497 people received a second MST at the end of the study. Analysis of the epidemiological data indicated that (i) 17% (16\/94) of all infections were subclinical, (ii) this percentage increased significantly with age, (iii) clinical infections led to 73\u00b79 % protective immunity (95 % C.I. 53\u00b70\u201385\u00b75 %) and relatively permanent MST responsiveness (recovery rate = 0\u00b70098\/year; 95% C.I. 0\u00b7000\u20130\u00b7020\/year), (iv) sub-clinical infections led to protective immunity, which was positively correlated with their MST induration size (increasing by 17\u00b79% per mm; <jats:italic>P<\/jats:italic> &lt; 0\u00b70001), and a mean MST recovery rate of 0\u00b7114\/year (4\/421 man-months), and (v) recurrent leishmaniasis was dominated by reactivations, not by reinfections.<\/jats:p>","DOI":"10.1017\/s0950268800057964","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T04:40:45Z","timestamp":1242362445000},"page":"297-318","source":"Crossref","is-referenced-by-count":62,"title":["Cutaneous leishmaniasis in the Peruvian Andes: an epidemiological study of infection and immunity"],"prefix":"10.1017","volume":"114","author":[{"given":"C. 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