{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:57:26Z","timestamp":1778637446756,"version":"3.51.4"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,10,19]],"date-time":"2009-10-19T00:00:00Z","timestamp":1255910400000},"content-version":"unspecified","delay-in-days":7993,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1987,12]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The standard six-dose intramuscular (i.m.) rabies post-exposure vaccine regimen using a new purified chick embryo cell (PCEC) vaccine was compared with two economical multisite intradermal (i.d.) PCEC regimens, a multisite i.m. PCEC schedule and a subcutaneous regimen using a suckling mouse brain (SMB) rabies vaccine manufactured in Thailand. The neutralizing antibody results for the four-site and eight-site i.d. and the standard i.m. PCEC regimens were similar over 3 months. A three-site i.m. PCEC regimen had no advantage. The SMB vaccine gave the lowest antibody levels. Human rabies immune globulin therapy significantly increased the GMT of all groups on day 7, unlike equine antirabies serum (EARS). Both antisera suppressed antibody responses to PCEC on days 14 and 28. Three generalized reactions probably related to EARS were the only serious side effects. An eight-site i.d. PCEC vaccine regimen proved as immunogenic as the routine i.m. schedule and, if implemented as post-exposure prophylaxis, would be the cheapest widely available tissue culture vaccine regimen. The protective efficiency should now be tested in patients bitten by rabid animals.<\/jats:p>","DOI":"10.1017\/s0950268800066619","type":"journal-article","created":{"date-parts":[[2009,10,19]],"date-time":"2009-10-19T08:44:02Z","timestamp":1255941842000},"page":"755-765","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":26,"title":["Purified chick embryo cell rabies vaccine: economical multisite intradermal regimen for post-exposure prophylaxis"],"prefix":"10.1017","volume":"99","author":[{"given":"Pravan","family":"Suntharasamai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Warrell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaisin","family":"Viravan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pornthep","family":"Chanthavanich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sornchai","family":"Looareesuwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achara","family":"Supapochana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juntra Karbwang Wichai","family":"Supanaranond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunee","family":"Chittamas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Bijok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A.","family":"Warrell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,10,19]]},"reference":[{"key":"S0950268800066619_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-1157(84)80019-0"},{"key":"S0950268800066619_ref007","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/133.Supplement_2.A266"},{"key":"S0950268800066619_ref015","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400066286"},{"key":"S0950268800066619_ref012","doi-asserted-by":"publisher","DOI":"10.1177\/004947558501500202"},{"key":"S0950268800066619_ref006","doi-asserted-by":"publisher","DOI":"10.1177\/004947558401400206"},{"key":"S0950268800066619_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91340-0"},{"key":"S0950268800066619_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91918-5"},{"key":"S0950268800066619_ref009","doi-asserted-by":"publisher","DOI":"10.2307\/4588549"},{"key":"S0950268800066619_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(87)90234-3"},{"key":"S0950268800066619_ref004","first-page":"393","volume-title":"Morbidity and Mortality Weekly Report","volume":"33","year":"1984"},{"key":"S0950268800066619_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92367-0"},{"key":"S0950268800066619_ref010","first-page":"109","article-title":"Incidence of reactions following administration of antirabies serum, study of 526 cases","volume":"193","author":"Karliner","year":"1965","journal-title":"Journal of the American Medical Association"},{"key":"S0950268800066619_ref011","first-page":"95","volume-title":"Improvements in Rabies Post-Exposure Treatment","author":"Ljubi\u010di\u0107","year":"1985"},{"key":"S0950268800066619_ref003","first-page":"155","article-title":"Purified chick embryo cell (PCEC) rabies vaccine for human use: clinical trials","volume":"76","author":"Bijok","year":"1984","journal-title":"Behring Instihit Mitteilungen"},{"key":"S0950268800066619_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-1157(82)80013-9"},{"key":"S0950268800066619_ref013","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/140.2.176"},{"key":"S0950268800066619_ref014","first-page":"115","article-title":"Studies with human diploid cells strain rabies vaccine and human antirabies immunoglobulin in man","volume":"40","author":"Nicholson","year":"1978","journal-title":"Developments of Biological Standardization"},{"key":"S0950268800066619_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90288-X"},{"key":"S0950268800066619_ref020","first-page":"85","volume-title":"Improvements in Rabies Post-Exposure Treatment","author":"Wasi","year":"1985"},{"key":"S0950268800066619_ref021","first-page":"125","article-title":"Protective antibodies after vaccination with human diploid cell rabies vaccine","volume":"1","author":"Wasi","year":"1983","journal-title":"Asian Pacific Journal of Allergy and Immunology"},{"key":"S0950268800066619_ref022","unstructured":"Who Expert Committee on Rabies (1984). Seventh Report. Technical Report Series 709. pp. 28\u201331. Geneva: World Health Organization."},{"key":"S0950268800066619_ref002","first-page":"103","volume-title":"Improvements in Babies Post-Exposure Treatment","author":"Bijok","year":"1985"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268800066619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T17:18:19Z","timestamp":1558372699000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268800066619\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,12]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1987,12]]}},"alternative-id":["S0950268800066619"],"URL":"https:\/\/doi.org\/10.1017\/s0950268800066619","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,12]]},"assertion":[{"value":"Cambridge University Press 1987","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}