{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T17:47:48Z","timestamp":1775152068329,"version":"3.50.1"},"reference-count":36,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,10,19]],"date-time":"2009-10-19T00:00:00Z","timestamp":1255910400000},"content-version":"unspecified","delay-in-days":6715,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1991,6]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>We conducted a 4-year retrospective cohort study to better define the risk of haemolytic anaemia and haemolytic uraemic syndrome (HUS) in children following sporadic gastrointestinal infection with the O 157.H7 serotype of<jats:italic>Escherichia coli<\/jats:italic>. Of the 72 children infected with this organism, 9 (12\u00b75%) developed haemolytic anaemia, 6 of whom had HUS. No child in a cohort of 72 age-matched controls with<jats:italic>Campylobacter jejuni<\/jats:italic>gastroenteritis developed haemolytic anaemia (<jats:italic>P<\/jats:italic>= 0\u00b7003). Females had a significantly greater risk of developing haemolytic anaemia after<jats:italic>E. coli<\/jats:italic>O 157.H7 infection than did males (8\/29 females<jats:italic>v.<\/jats:italic>1\/43 males;<jats:italic>P<\/jats:italic>= 0\u00b7003). In a logistic regression model, female gender emerged as the only statistically significant risk factor for haemolytic anaemia (odds ratio 3\u00b785; 95% confidence interval 1\u00b724\u201312). These results are consistent with recent reports of a moderate increase in the risk of HUS for females.<\/jats:p>","DOI":"10.1017\/s0950268800067583","type":"journal-article","created":{"date-parts":[[2009,10,19]],"date-time":"2009-10-19T12:39:57Z","timestamp":1255955997000},"page":"523-530","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":17,"title":["Haemolytic anaemia after childhood<i>Escherichia coli<\/i>O 157.H7 infection: are females at increased risk?"],"prefix":"10.1017","volume":"106","author":[{"given":"P. C.","family":"Rowe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Walop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Lior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Mackenzie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,10,19]]},"reference":[{"key":"S0950268800067583_ref036","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)92287-8"},{"key":"S0950268800067583_ref035","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.1982.tb00786.x"},{"key":"S0950268800067583_ref033","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/151.6.988"},{"key":"S0950268800067583_ref032","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1542\/peds.47.1.120","article-title":"A sex difference in immunologic responsiveness","volume":"47","author":"Michaels","year":"1971","journal-title":"Pediatrics"},{"key":"S0950268800067583_ref031","first-page":"1251","article-title":"Immunological bases for superior survival of females","volume":"133","author":"Purtilo","year":"1979","journal-title":"Am J Dis Child"},{"key":"S0950268800067583_ref030","unstructured":"30. 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Unpublished observations."},{"key":"S0950268800067583_ref028","doi-asserted-by":"publisher","DOI":"10.1007\/BF00858441"},{"key":"S0950268800067583_ref027","doi-asserted-by":"publisher","DOI":"10.1159\/000185286"},{"key":"S0950268800067583_ref026","doi-asserted-by":"crossref","first-page":"8834","DOI":"10.1016\/S0021-9258(18)47490-X","article-title":"Glycolipid binding of purified and recombinant Escherichia coli produced verotoxin in vitro","volume":"262","author":"Lingwood","year":"1987","journal-title":"J Biol Chem"},{"key":"S0950268800067583_ref025","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-198910000-00012"},{"key":"S0950268800067583_ref023","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.292.6513.115"},{"key":"S0950268800067583_ref019","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-198603000-00015"},{"key":"S0950268800067583_ref018","first-page":"333A","article-title":"members of the pediatrics section of the Canadian Society of Nephrology","volume":"27","author":"McLaine","journal-title":"A collaborative study of childhood HUS in Canada, 1986\u20131988"},{"key":"S0950268800067583_ref015","first-page":"540","article-title":"Rapid and specific detection of verotoxin genes in Escherichia coli by the polymerase chain reaction","volume":"28","author":"Pollard","year":"1990","journal-title":"J din Microbiol"},{"key":"S0950268800067583_ref014","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1128\/IAI.18.3.775-779.1977","article-title":"Vero response to a cytotoxin of Escherichia coli","volume":"18","author":"Konowalchuk","year":"1977","journal-title":"Infect Immun"},{"key":"S0950268800067583_ref012","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/157.5.1054"},{"key":"S0950268800067583_ref011","first-page":"604","article-title":"Outbreak of gastrointestinal disease in Sarnia, Ontario","volume":"7","author":"Duncan","year":"1986","journal-title":"Ontario Dis Surveillance Rep"},{"key":"S0950268800067583_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)80386-9"},{"key":"S0950268800067583_ref009","first-page":"37","article-title":"Escherichia coli 0 157","volume":"80","author":"MA","year":"1987","journal-title":"H7 as the predominant pathogen associated with the hemolytic uremic syndrome: a prospective study in the Pacific Northwest. 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