{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T23:17:02Z","timestamp":1649200622059},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,10,19]],"date-time":"2009-10-19T00:00:00Z","timestamp":1255910400000},"content-version":"unspecified","delay-in-days":6045,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1993,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>One hundred and ninety-two strains of <jats:italic>Neisseria gonorrhoeae<\/jats:italic> isolated from migrant mine-workers were tested for their susceptibility to antibiotics, auxotyped and serotyped. Of the total, 93 (48%) were acquired locally and 64 (33%) from different geographical locations. Plasmid-mediated resistance to penicillin was found in 28 (14\u00b76%) strains and was associated predominantly with the presence of 5\u00b70 kb penicillinase encoding plasmid (18\/28, 64%). Chromosomal resistance to penicillin (MIC \u2265 1 mg\/l) was detected in 14 (7\u00b73%) strains. Resistance to tetracycline was chromosomally and not plasmid-mediated. Antibiotic resistance was encountered most commonly among strains acquired in Natal. The overall gonococcal population was sensitive to ceftriaxone, ciprofloxacin. spectinomycin and azithromycin. Nine auxotype\/serovar (A\/S) classes were encountered among penicillinase-producing <jats:italic>N. gonorrhoeae<\/jats:italic> (PPNG) compared to 24 A\/S classes among non-PPNG strains. The most common A\/S class was NR\/IA-6 which accounted for 38% of PPNG and 15% of non-PPNG.<\/jats:p>","DOI":"10.1017\/s0950268800068230","type":"journal-article","created":{"date-parts":[[2009,10,19]],"date-time":"2009-10-19T12:39:50Z","timestamp":1255955990000},"page":"297-305","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":10,"title":["Antimicrobial susceptibilities and serotyping of <i>Neisseria gonorrhoeae<\/i> in southern Africa: influence of geographical source of infection"],"prefix":"10.1017","volume":"110","author":[{"given":"C. A.","family":"Ison","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. 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with modified New York City medium (MNYC)"},{"key":"S0950268800068230_ref007","first-page":"44","volume":"150","author":"Knapp","year":"1984","journal-title":"Serological classification of Neisseria gonorrhoeae with use of monoclonal antibodies to gonococcal outer membrane protein I"},{"key":"S0950268800068230_ref008","first-page":"295","volume":"16","author":"Copley","year":"1983","journal-title":"Auxotyping of Neisseria gonorrhoeae isolated in the United Kingdom"},{"key":"S0950268800068230_ref012","volume-title":"STD treatment strategies","year":"1989"},{"key":"S0950268800068230_ref013","first-page":"187","volume":"78","author":"Hoosen","year":"1990","journal-title":"Efficacy of various single-dose regimens of ceftriaxone in uncomplicated acute gonococcal urethritis in adult males"},{"key":"S0950268800068230_ref017","first-page":"676","volume":"i","author":"Anderson","year":"1982","journal-title":"Penicillinase-producing Neisseria gonorrhoeae from strains from Nigeria with Far Eastern type plasmid"},{"key":"S0950268800068230_ref020","first-page":"669","volume":"99","author":"Johnson","year":"1987","journal-title":"Plasmid content, auxotype and protein I serovar of gonococci isolated in The Gambia"},{"key":"S0950268800068230_ref016","first-page":"630","volume":"266","author":"Roberts","year":"1977","journal-title":"Conjugal transfer of R plasmid in Neisseria gonorrhoeae"},{"key":"S0950268800068230_ref022","first-page":"41","volume":"59","author":"Odugbemi","year":"1983","journal-title":"Plasmid profile, serogrouping and auxotyping of Neisseria gonorrhoeae isolates from Africa"},{"key":"S0950268800068230_ref026","first-page":"350","volume":"68","author":"Ison","year":"1992","journal-title":"The dominance of a multiresistant strain of Neisseria gonorrhoeae among prostitutes and STD patients in The Gambia"},{"key":"S0950268800068230_ref009","first-page":"239","volume":"63","author":"Ison","year":"1987","journal-title":"Chromosomal resistance of gonoeocci to 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