{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T11:03:16Z","timestamp":1768906996837,"version":"3.49.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2003,10,7]],"date-time":"2003-10-07T00:00:00Z","timestamp":1065484800000},"content-version":"unspecified","delay-in-days":6,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:p>Group B streptococcal isolates (<jats:italic>n<\/jats:italic>=159) from the three Dublin maternity hospitals, were serotyped and analysed for the <jats:italic>bac<\/jats:italic>, <jats:italic>bca<\/jats:italic>, <jats:italic>hylB<\/jats:italic>, <jats:italic>pepB<\/jats:italic>, and <jats:italic>rib<\/jats:italic> genes. The serotype distribution of the isolates was Ia, 19\u00b75%; Ib, 18\u00b79%; II, 10\u00b77%; III, 29\u00b75%; IV, 1\u00b79%; V, 15\u00b71%; non-typeable, 4\u00b74%. There was a statistically significant association between the serotype and invasive status (carriage or infection) of isolates (<jats:italic>P<\/jats:italic>&lt;0\u00b7005), but no significant association between serotype and degree of invasiveness was demonstrated. The presence or absence of each analysed gene was not associated with the invasive status of isolates. Statistically significant associations were revealed between <jats:italic>bca<\/jats:italic> and <jats:italic>hylB<\/jats:italic> (IS<jats:italic>1548<\/jats:italic>) (<jats:italic>P<\/jats:italic>=0\u00b70004) and between <jats:italic>bac<\/jats:italic> and <jats:italic>bca<\/jats:italic> (<jats:italic>P<\/jats:italic>=0\u00b70l4). The <jats:italic>bac<\/jats:italic>, <jats:italic>bca<\/jats:italic>, <jats:italic>hylB<\/jats:italic> (IS<jats:italic>1548<\/jats:italic>) and <jats:italic>rib<\/jats:italic> genes and the numbers of tandem repeats in the <jats:italic>bca<\/jats:italic> gene showed significant associations with serotype. Almost 50% of serotype III isolates possessed at least one of the <jats:italic>bac<\/jats:italic> and <jats:italic>bca<\/jats:italic> genes and 55\u201365% of strains of serotypes Ia, Ib and II possessed the <jats:italic>rib<\/jats:italic> gene. Most serotype III isolates had IS<jats:italic>1548<\/jats:italic> in their <jats:italic>hylB<\/jats:italic> genes. Serotype Ib was the only serotype in which more than half of the strains contained more tandem repeats in the <jats:italic>bca<\/jats:italic> gene than the overall mean for the GBS population studied of 7\u00b74 repeats. These findings indicate that some previously reported associations between putative virulence factors and GBS disease require further study and clarification.<\/jats:p>","DOI":"10.1017\/s0950268803008847","type":"journal-article","created":{"date-parts":[[2003,10,7]],"date-time":"2003-10-07T14:02:18Z","timestamp":1065535338000},"page":"823-833","source":"Crossref","is-referenced-by-count":23,"title":["Molecular epidemiology of group B streptococci in Ireland: associations between serotype, invasive status and presence of genes encoding putative virulence factors"],"prefix":"10.1017","volume":"131","author":[{"given":"N.","family":"DORE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"BENNETT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"KALISZER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"CAFFERKEY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J.","family":"SMYTH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2003,10,7]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268803008847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T22:32:28Z","timestamp":1557181948000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268803008847\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["S0950268803008847"],"URL":"https:\/\/doi.org\/10.1017\/s0950268803008847","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10]]}}}