{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T02:04:42Z","timestamp":1773108282985,"version":"3.50.1"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2004,10,6]],"date-time":"2004-10-06T00:00:00Z","timestamp":1097020800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:p>A total of 162 clinical isolates of <jats:italic>Shigella<\/jats:italic> collected from children in a semi-rural community of Chile were examined for the presence of genetic determinants of resistance to ampicillin, chloramphenicol, tetracycline, and trimethoprim. Ampicillin resistance was most frequently associated with the presence of <jats:italic>bla<\/jats:italic><jats:sub>OXA<\/jats:sub> in <jats:italic>S. flexneri<\/jats:italic> and with <jats:italic>bla<\/jats:italic><jats:sub>TEM<\/jats:sub> in <jats:italic>S. sonnei<\/jats:italic>. The <jats:italic>bla<\/jats:italic><jats:sub>OXA<\/jats:sub> gene but not <jats:italic>bla<\/jats:italic><jats:sub>TEM<\/jats:sub> was located in class 1 integrons. The <jats:italic>dhfr<\/jats:italic>Ia gene encoding for resistance to trimethoprim was associated to class 2 integrons and detected exclusively in <jats:italic>S. flexneri<\/jats:italic>, whereas <jats:italic>dhfr<\/jats:italic>IIIc was found in all <jats:italic>S. sonnei<\/jats:italic> strains and in 10% of the <jats:italic>S. flexneri<\/jats:italic> isolates. <jats:italic>Cat<\/jats:italic>, coding for choramphenicol resistance, and <jats:italic>bla<\/jats:italic><jats:sub>OXA<\/jats:sub> genes were located in the chromosome in all cases, whereas <jats:italic>tetA<\/jats:italic> gene, coding for tetracycline resistance, and <jats:italic>bla<\/jats:italic><jats:sub>TEM<\/jats:sub>, <jats:italic>dhfr<\/jats:italic>Ia and <jats:italic>dhfr<\/jats:italic>IIIc genes were found either in the chromosome or in conjugative plasmids. Our results show a heterogenous distribution of antibiotic-resistance determinants between <jats:italic>S. flexneri<\/jats:italic> and <jats:italic>S. sonnei<\/jats:italic>.<\/jats:p>","DOI":"10.1017\/s0950268804003048","type":"journal-article","created":{"date-parts":[[2005,1,17]],"date-time":"2005-01-17T12:19:59Z","timestamp":1105964399000},"page":"81-86","source":"Crossref","is-referenced-by-count":67,"title":["Genetic analysis of antibiotic-resistance determinants in multidrug-resistant <i>Shigella<\/i> strains isolated from Chilean children"],"prefix":"10.1017","volume":"133","author":[{"given":"C. S.","family":"TORO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"FARF\u00c1N","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"CONTRERAS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"FLORES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"NAVARRO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. C.","family":"MORA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"PRADO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2004,10,6]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268804003048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T19:47:14Z","timestamp":1554580034000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268804003048\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10,6]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["S0950268804003048"],"URL":"https:\/\/doi.org\/10.1017\/s0950268804003048","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10,6]]}}}