{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:55:28Z","timestamp":1787061328388,"version":"build-2736575974"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2005,4,25]],"date-time":"2005-04-25T00:00:00Z","timestamp":1114387200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p>\n                    Asymptomatic carriage of\n                    <jats:italic>Neisseria meningitidis<\/jats:italic>\n                    is common (5\u201335% of individuals) while the incidence of invasive meningococcal disease is fairly low (&lt;1\u20135 per 100000 per annum in Europe). Naturally acquired protective immunity may account for this difference. In this study, we investigated the relationship between anti-meningococcal salivary IgA and age and carriage. We showed that salivary IgA to a range of meningococcal antigens increased successively with age with some specificity for commonly circulating serosubtypes. In a group of 258 students 37 (14%) of whom were carriers of\n                    <jats:italic>N. meningitidis<\/jats:italic>\n                    serogroup B, higher levels of specific IgA were associated with carriage. Stratified analysis revealed a positive relationship between smoking and specific anti-\n                    <jats:italic>N. meningitidis<\/jats:italic>\n                    IgA independent of current carriage, weighted odds ratio (OR) 4\u00b71 (95% CI 1\u00b71\u201318) and OR 3\u00b78 (95% CI 0\u00b796\u201316) for reference strains B:1:P1.14 and B:4:P1.5,4 respectively. These data implicate IgA as a factor in host defence from meningococcal invasion, although the precise mechanisms remain uncertain.\n                  <\/jats:p>","DOI":"10.1017\/s0950268805004097","type":"journal-article","created":{"date-parts":[[2005,9,26]],"date-time":"2005-09-26T05:59:47Z","timestamp":1127714387000},"page":"883-889","source":"Crossref","is-referenced-by-count":25,"title":["Influence of age and carriage status on salivary IgA to\n                    <i>Neisseria meningitidis<\/i>"],"prefix":"10.1017","volume":"133","author":[{"given":"R. E.","family":"HORTON","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"STUART","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"CHRISTENSEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"BORROW","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"GUTHRIE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"DAVENPORT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"FINN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"The ALSPAC Study Team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. A.","family":"WILLIAMS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. S.","family":"HEYDERMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2005,4,25]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268805004097","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T15:57:17Z","timestamp":1556899037000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268805004097\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,25]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["S0950268805004097"],"URL":"https:\/\/doi.org\/10.1017\/s0950268805004097","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4,25]]}}}