{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T05:35:51Z","timestamp":1776836151973,"version":"3.51.2"},"reference-count":40,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2005,6,30]],"date-time":"2005-06-30T00:00:00Z","timestamp":1120089600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Mycobacterium avium<\/jats:italic>\n                    subspecies\n                    <jats:italic>paratuberculosis<\/jats:italic>\n                    (\n                    <jats:italic>Map<\/jats:italic>\n                    ), the cause of ruminant paratuberculosis, has been proposed as the causative agent of Crohn's disease. The objective of this study was to determine whether exposure to clinical cases of bovine paratuberculosis was a risk factor for Crohn's disease. A questionnaire was sent to dairy farmers living on premises where the occurrence or absence of clinical cases of bovine paratuberculosis had previously been determined. The prevalence of Crohn's disease was found to be similar to that reported in other studies in the United Kingdom and showed no association with bovine paratuberculosis. There was, however, a univariate association with geographical region. Ulcerative colitis showed univariate associations with age, frequency of contact with cattle and with smoking. The results do not support the hypothesis that\n                    <jats:italic>Map<\/jats:italic>\n                    plays a causative role in the aetiology of Crohn's disease.\n                  <\/jats:p>","DOI":"10.1017\/s0950268805004681","type":"journal-article","created":{"date-parts":[[2005,6,30]],"date-time":"2005-06-30T05:44:50Z","timestamp":1120110290000},"page":"49-56","source":"Crossref","is-referenced-by-count":42,"title":["Crohn's disease in people exposed to clinical cases of bovine paratuberculosis"],"prefix":"10.1017","volume":"134","author":[{"given":"P.\u00a0H.","family":"JONES","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.\u00a0B.","family":"FARVER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"BEAMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"\u00c7ETINKAYA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.\u00a0L.","family":"MORGAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2005,6,30]]},"reference":[{"key":"S0950268805004681_ref033","doi-asserted-by":"publisher","DOI":"10.1136\/gut.26.3.274"},{"key":"S0950268805004681_ref039","first-page":"321","volume-title":"Sixth International Colloquium on Paratuberculosis: Diagnostic Applications and Approaches","author":"Pavlik","year":"1999"},{"key":"S0950268805004681_ref023","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1992.tb02979.x"},{"key":"S0950268805004681_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(03)00724-2"},{"key":"S0950268805004681_ref036","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.11.1547"},{"key":"S0950268805004681_ref040","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.68.2.602-607.2002"},{"key":"S0950268805004681_ref026","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.7.2915-2923.2003"},{"key":"S0950268805004681_ref009","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200306000-00006"},{"key":"S0950268805004681_ref025","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.5.665"},{"key":"S0950268805004681_ref017","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.9.1209"},{"key":"S0950268805004681_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0720(15)30417-5"},{"key":"S0950268805004681_ref035","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90826-K"},{"key":"S0950268805004681_ref013","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1128\/JCM.25.5.796-801.1987","article-title":"Crohn's disease-isolated mycobacteria are identical to Mycobacterium paratuberculosis, as determined by DNA probes that distinguish between mycobacterial species","volume":"25","author":"McFadden","year":"1987","journal-title":"J Clin Microbiol"},{"key":"S0950268805004681_ref012","doi-asserted-by":"publisher","DOI":"10.1007\/BF01317078"},{"key":"S0950268805004681_ref018","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2000.00093.x"},{"key":"S0950268805004681_ref001","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.3.309"},{"key":"S0950268805004681_ref002","doi-asserted-by":"publisher","DOI":"10.1038\/35079107"},{"key":"S0950268805004681_ref032","doi-asserted-by":"publisher","DOI":"10.1007\/BF02393573"},{"key":"S0950268805004681_ref019","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s002849900430","article-title":"Characterization of Mycobacterium paratuberculosis p36 antigen and its seroreactivities in Crohn's disease","volume":"39","author":"El-Zaatari","year":"1999","journal-title":"Curr Microbiol"},{"key":"S0950268805004681_ref004","first-page":"144","article-title":"Inflammatory bowel disease and smoking\u00a0\u2013\u00a0a review","volume":"93","author":"Thomas","year":"1998","journal-title":"Am J Gastroenterol"},{"key":"S0950268805004681_ref005","doi-asserted-by":"publisher","DOI":"10.1136\/gut.37.5.668"},{"key":"S0950268805004681_ref006","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2.218"},{"key":"S0950268805004681_ref007","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020831"},{"key":"S0950268805004681_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07284-7"},{"key":"S0950268805004681_ref037","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00886.x"},{"key":"S0950268805004681_ref011","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1128\/JCM.20.5.966-971.1984","article-title":"Characteristics of an unclassified Mycobacterium species isolated from patients with Crohn's disease","volume":"20","author":"Chiodini","year":"1984","journal-title":"J Clin Microbiol"},{"key":"S0950268805004681_ref015","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1128\/JCM.31.5.1241-1245.1993","article-title":"Identification of spheroplast-like agents isolated from tissues of patients with Crohn's disease and control tissues by polymerase chain reaction","volume":"31","author":"Wall","year":"1993","journal-title":"J Clin Microbiol"},{"key":"S0950268805004681_ref021","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/89.3.217"},{"key":"S0950268805004681_ref031","doi-asserted-by":"publisher","DOI":"10.1136\/vr.143.10.265"},{"key":"S0950268805004681_ref022","first-page":"G3220","article-title":"Serum antibodies to Mycobacterium paratuberculosis in Japanese patients with Crohn's disease: an immunoblot assay","volume":"116","author":"Ishii","year":"1999","journal-title":"Gastroenterology"},{"key":"S0950268805004681_ref024","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1995.tb03837.x"},{"key":"S0950268805004681_ref028","first-page":"217","article-title":"Mycobacterium paratuberculosis and inflammatory bowel disease: frequency distribution in serial colonoscopic biopsies using the polymerase chain reaction","volume":"83","author":"Murray","year":"1995","journal-title":"Microbios"},{"key":"S0950268805004681_ref029","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)92280-X"},{"key":"S0950268805004681_ref030","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5877(97)00028-7"},{"key":"S0950268805004681_ref020","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026692627460"},{"key":"S0950268805004681_ref034","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.11.1262"},{"key":"S0950268805004681_ref038","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198703193161202"},{"key":"S0950268805004681_ref003","doi-asserted-by":"publisher","DOI":"10.1038\/35079114"},{"key":"S0950268805004681_ref027","doi-asserted-by":"publisher","DOI":"10.1007\/s005350050244"},{"key":"S0950268805004681_ref014","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1128\/JCM.24.3.357-363.1986","article-title":"Spheroplastic phase of mycobacteria isolated from patients with Crohn's disease","volume":"24","author":"Chiodini","year":"1986","journal-title":"J Clin Microbiol"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268805004681","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T22:18:16Z","timestamp":1586297896000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268805004681\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,30]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S0950268805004681"],"URL":"https:\/\/doi.org\/10.1017\/s0950268805004681","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.8368.465859","asserted-by":"object"}]},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,30]]}}}