{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T23:08:59Z","timestamp":1722208139165},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2005,8,19]],"date-time":"2005-08-19T00:00:00Z","timestamp":1124409600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p>The lymphocyte profile of 521 HIV-infected subjects hospitalized at Jackson Memorial (2001\u20132002) was compared across main respiratory diseases. Study data included medical history and all laboratory evaluations performed during hospitalization. Community-acquired pneumonias (CAP, 52%), <jats:italic>Pneumocystis jiroveci<\/jats:italic> pneumonia (PCP, 24%), tuberculosis (TB, 9%) and non-tuberculous mycobacterial diseases (NTM, 12%) were the most frequent causes of admission. Patients hospitalized with PCP and NTM exhibited the lowest CD4 counts (<jats:italic>P<\/jats:italic>=0\u00b7003). PCP patients had the highest B-cell percentages (<jats:italic>P<\/jats:italic>=0\u00b704). CAP patients had the highest CD8 and CD4 percentages and the lowest percentage of Natural Killer (NK) cells and viral burdens. TB patients exhibited the lowest NK-cell (11\u00b74\u00b16\u00b73) and B-cell percentages (13\u00b76\u00b112) and the highest CD8 (59\u00b114) percentage. NTM patients, in contrast, had the highest NK-cell percentages of the groups (19\u00b71\u00b111\u00b76, <jats:italic>P<\/jats:italic>=0\u00b701). Additionally, immune responses associated with respiratory pathogens differed in HIV-infected patients with CD4+ cells above and below 200 counts.<\/jats:p>","DOI":"10.1017\/s0950268805005030","type":"journal-article","created":{"date-parts":[[2005,8,19]],"date-time":"2005-08-19T10:25:40Z","timestamp":1124447140000},"page":"271-278","source":"Crossref","is-referenced-by-count":3,"title":["Cellular immune response to pulmonary infections in HIV-infected individuals hospitalized with diverse grades of immunosuppression"],"prefix":"10.1017","volume":"134","author":[{"given":"M. J.","family":"MIGUEZ-BURBANO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"ASHKIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"RODRIGUEZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"DUNCAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"FLORES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"ACOSTA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"QUINTERO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"PITCHENIK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2005,8,19]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268805005030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T20:20:07Z","timestamp":1555014007000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268805005030\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,19]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["S0950268805005030"],"URL":"https:\/\/doi.org\/10.1017\/s0950268805005030","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8,19]]}}}