{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:24:41Z","timestamp":1791095081636,"version":"4.1.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2006,5,11]],"date-time":"2006-05-11T00:00:00Z","timestamp":1147305600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>\n                    Ninety-seven isolates of\n                    <jats:italic>Shigella flexneri<\/jats:italic>\n                    from children seeking medical care from three sites in Egypt were characterized. Overall, 46\u00b74% of children (median age 17 months) were febrile or reported blood in their stools, 25\u00b78% were dehydrated and 16\u00b75% were admitted to hospital. Serotypes 2a (37\u00b71%), 1b (18\u00b76%), 1c (17\u00b75%), and 6 (15\u00b75%) comprised over 88\u00b77% of the total isolates. We observed marked resistance to ampicillin (87\u00b76%), tetracycline (84\u00b75%) and trimethoprim\u2013sulfamethoxazole (63\u00b79%). Pulsed-field electrophoresis grouped the majority of isolates within a serotype together, separately from isolates of an alternative serotype. The\n                    <jats:italic>set<\/jats:italic>\n                    gene was present in all serogroup 2a isolates, however, the\n                    <jats:italic>sen<\/jats:italic>\n                    gene was detected in every isolate. Our results show\n                    <jats:italic>S. flexneri<\/jats:italic>\n                    1c has emerged as a dominant\n                    <jats:italic>S. flexneri<\/jats:italic>\n                    serotype in Egypt. Development and application of a\n                    <jats:italic>Shigella<\/jats:italic>\n                    vaccine should consider the diversity of\n                    <jats:italic>Shigella<\/jats:italic>\n                    serotypes within a geographical region prior to administration.\n                  <\/jats:p>","DOI":"10.1017\/s095026880600642x","type":"journal-article","created":{"date-parts":[[2006,5,11]],"date-time":"2006-05-11T10:56:00Z","timestamp":1147344960000},"page":"1237-1248","source":"Crossref","is-referenced-by-count":28,"title":["Epidemiology and genetic characterization of\n                    <i>Shigella flexneri<\/i>\n                    strains isolated from three paediatric populations in Egypt (2000\u20132004)"],"prefix":"10.1017","volume":"134","author":[{"given":"S. F.","family":"AHMED","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"RIDDLE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. F.","family":"WIERZBA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. ABDEL","family":"MESSIH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"MONTEVILLE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. W.","family":"SANDERS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. D.","family":"KLENA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2006,5,11]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S095026880600642X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T15:30:56Z","timestamp":1556811056000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S095026880600642X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,11]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S095026880600642X"],"URL":"https:\/\/doi.org\/10.1017\/s095026880600642x","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,11]]}}}