{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T13:30:48Z","timestamp":1769002248454,"version":"3.49.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2006,6,26]],"date-time":"2006-06-26T00:00:00Z","timestamp":1151280000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p>The stability of IS<jats:italic>6110<\/jats:italic> restriction fragment length polymorphism (RFLP) pattern was determined in 31 isolates from patients with multidrug-resistant tuberculosis (MDR-TB). These patients were in actual chains of transmission and they referred to the National Institute of Tuberculosis and Lung Diseases, Tehran, Iran. Susceptibility testing against first- and second-line drugs were performed by the proportional method on Lowenstein\u2013Jensen culture media. Thereafter, DNA fingerprinting by IS<jats:italic>6110<\/jats:italic> with direct repeat (DR) region as a probe was performed by standard protocols. The rate of IS<jats:italic>6110<\/jats:italic> changes was 16%, although, no variation was found in the DR region, in a time-span of 1\u201363 months. The strains with unstable IS<jats:italic>6110<\/jats:italic> patterns were resistant to all drugs tested, and the majority of them (60%) were collected from HIV-positive patients. The results demonstrated that for a reliable interpretation of strain typing, it is better to use an additional marker along with IS<jats:italic>6110<\/jats:italic> RFLP.<\/jats:p>","DOI":"10.1017\/s0950268806006790","type":"journal-article","created":{"date-parts":[[2007,2,9]],"date-time":"2007-02-09T13:36:42Z","timestamp":1171028202000},"page":"346-352","source":"Crossref","is-referenced-by-count":9,"title":["Instability of IS<i>6110<\/i> patterns in multidrug-resistant strains of <i>Mycobacterium tuberculosis<\/i>"],"prefix":"10.1017","volume":"135","author":[{"given":"P.","family":"FARNIA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. R.","family":"MASJEDI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"NASIRI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"MIRSAEDI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"SOROOCH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"KAZEAMPOUR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A.","family":"VELAYATI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2006,6,26]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268806006790","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T20:09:05Z","timestamp":1554322145000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268806006790\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,26]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S0950268806006790"],"URL":"https:\/\/doi.org\/10.1017\/s0950268806006790","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,26]]}}}