{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:07:57Z","timestamp":1784074077021,"version":"3.55.0"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2006,11,17]],"date-time":"2006-11-17T00:00:00Z","timestamp":1163721600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Reduction of the antioxidant capacity of plasma has been linked with the impairment of an effective immune response and so we hypothesized that the carriage rate of<jats:italic>Neisseria meningitidis<\/jats:italic>in asymptomatic subjects might correlate with the levels of antioxidants in plasma. To this end we took pharyngeal swabs from 339 children in Marquesado Basic Health Zone, Granada, Spain and in addition determined the total antioxidant capacity (TAC) in plasma samples from these subjects. The overall prevalence of<jats:italic>N. meningitidis<\/jats:italic>carriage was 5\u00b79% (mean age 7\u00b71 years) with rates of 10\u00b73% in children aged \u2a7d3 years, 3\u00b79% between 4 and 7 years and 2\u00b74% in older subjects. Plasma TAC for the \u2a7d3-year-olds was 0\u00b713 for carriers and 1\u00b710 for non-carrier controls (<jats:italic>P<\/jats:italic>=0\u00b704), 0\u00b713 for carriers aged 4\u20137 years (controls 0\u00b763) and 0\u00b728 for carriers aged &gt;7 years (controls 0\u00b752). We analysed the association between TAC in plasma (&lt;0\u00b737\u00a0\u2013\u00a02<jats:sc>s.d<\/jats:sc>.) and the carrier state of<jats:italic>N. meningitidis<\/jats:italic>. In the carrier state, the odds ratio for this association (TAC in plasma &lt;0\u00b725) was 8\u00b744 (95% CI 1\u00b75\u201348\u00b79). These findings may suggest a reduced immune response in the host favourable to nasopharyngeal persistence of meningococci.<\/jats:p>","DOI":"10.1017\/s0950268806007539","type":"journal-article","created":{"date-parts":[[2006,11,17]],"date-time":"2006-11-17T08:31:45Z","timestamp":1163752305000},"page":"857-860","source":"Crossref","is-referenced-by-count":11,"title":["Total antioxidant capacity of plasma in asymptomatic carrier state of<i>Neisseria meningitidis<\/i>"],"prefix":"10.1017","volume":"135","author":[{"given":"J.","family":"UBEROS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"MOLINA-CARBALLO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"GALDO-MU\u00d1OZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"MU\u00d1OZ-HOYOS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2006,11,17]]},"reference":[{"key":"S0950268806007539_ref003","doi-asserted-by":"publisher","DOI":"10.1136\/ewjm.173.2.125"},{"key":"S0950268806007539_ref004","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.325.7360.365"},{"key":"S0950268806007539_ref008","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111451200"},{"key":"S0950268806007539_ref005","doi-asserted-by":"publisher","DOI":"10.1086\/339010"},{"key":"S0950268806007539_ref006","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.1.271"},{"key":"S0950268806007539_ref009","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940201)73:3<699::AID-CNCR2820730332>3.0.CO;2-L"},{"key":"S0950268806007539_ref018","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7159.621"},{"key":"S0950268806007539_ref017","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015696513062"},{"key":"S0950268806007539_ref011","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6890-2-3"},{"key":"S0950268806007539_ref015","first-page":"1","article-title":"Prevention and control of meningococcal disease: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"46","year":"1997","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"S0950268806007539_ref007","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200323898"},{"key":"S0950268806007539_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2006.03.019"},{"key":"S0950268806007539_ref001","doi-asserted-by":"crossref","first-page":"573","DOI":"10.5694\/j.1326-5377.2002.tb04586.x","article-title":"The control of meningococcal disease","volume":"176","author":"Hall","year":"2002","journal-title":"Medical Journal of Australia"},{"key":"S0950268806007539_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(90)90006-5"},{"key":"S0950268806007539_ref016","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268801006173"},{"key":"S0950268806007539_ref010","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1999.4010"},{"key":"S0950268806007539_ref002","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeg005"},{"key":"S0950268806007539_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2005.12.012"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268806007539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T01:05:49Z","timestamp":1587258349000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268806007539\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,17]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S0950268806007539"],"URL":"https:\/\/doi.org\/10.1017\/s0950268806007539","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,17]]}}}