{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:24:56Z","timestamp":1791293096811,"version":"4.1.0"},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2006,12,7]],"date-time":"2006-12-07T00:00:00Z","timestamp":1165449600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Although community-onset bloodstream infection (BSI) is recognized to be a major cause of morbidity and mortality, there is a paucity of population-based studies defining its overall burden. We conducted population-based laboratory surveillance for all community-onset BSI in the Calgary Health Region during 2000\u20132004. A total of 4467 episodes of community-onset BSI were identified for an overall annual incidence of 81\u00b76\/100 000. The three species,<jats:italic>Escherichia coli<\/jats:italic>,<jats:italic>Staphylococcus aureus<\/jats:italic>, and<jats:italic>Streptococcus pneumoniae<\/jats:italic>were responsible for the majority of community-onset BSI; they occurred at annual rates of 25\u00b78, 13\u00b75, and 10\u00b71\/100 000, respectively. Overall 3445\/4467 (77%) episodes resulted in hospital admission representing 0\u00b77% of all admissions to major acute care hospitals. The subsequent hospital length of stay was a median of 9 (interquartile range, 5\u201315) days; the total days of acute hospitalization attributable to community-onset BSI was 51 146 days or 934 days\/100 000 annually. Four hundred and sixty patients died in hospital for a case-fatality rate of 13%. Community-onset BSI is common and has a major patient and societal impact. These data support further efforts to reduce the burden of community-onset BSI.<\/jats:p>","DOI":"10.1017\/s0950268806007631","type":"journal-article","created":{"date-parts":[[2006,12,7]],"date-time":"2006-12-07T14:06:16Z","timestamp":1165500376000},"page":"1037-1042","source":"Crossref","is-referenced-by-count":104,"title":["Burden of community-onset bloodstream infection: a population-based assessment"],"prefix":"10.1017","volume":"135","author":[{"given":"K.\u00a0B.","family":"LAUPLAND","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.\u00a0B.","family":"GREGSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.\u00a0W.","family":"FLEMONS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"HAWKINS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"ROSS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.\u00a0L.","family":"CHURCH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2006,12,7]]},"reference":[{"key":"S0950268806007631_ref003","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1999.tb01563.x"},{"key":"S0950268806007631_ref022","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100003504"},{"key":"S0950268806007631_ref001","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.8.3655-3660.2003"},{"key":"S0950268806007631_ref015","doi-asserted-by":"publisher","DOI":"10.1086\/421094"},{"key":"S0950268806007631_ref007","doi-asserted-by":"publisher","DOI":"10.1186\/cc2952"},{"key":"S0950268806007631_ref008","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.05503-0"},{"key":"S0950268806007631_ref026","first-page":"185","article-title":"Outpatient parenteral antibiotic therapy: evolution of the Calgary adult home parenteral therapy program","volume":"25","author":"Laupland","year":"2002","journal-title":"Clinical and Investigative Medicine"},{"key":"S0950268806007631_ref005","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-5-35"},{"key":"S0950268806007631_ref021","first-page":"213","article-title":"Acute myocardial infarction in Alberta: temporal changes in outcomes, 1994 to 1999","volume":"20","author":"Quan","year":"2004","journal-title":"Canadian Journal of Cardiology"},{"key":"S0950268806007631_ref004","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2004.01269.x"},{"key":"S0950268806007631_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2005.02.005"},{"key":"S0950268806007631_ref006","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2003.00599.x"},{"key":"S0950268806007631_ref009","doi-asserted-by":"publisher","DOI":"10.1086\/429344"},{"key":"S0950268806007631_ref024","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.5694\/j.1326-5377.2000.tb139411.x","article-title":"Invasive pneumococcal disease in the population of Victoria","volume":"173","author":"Hogg","year":"2000","journal-title":"Medical Journal of Australia"},{"key":"S0950268806007631_ref010","doi-asserted-by":"publisher","DOI":"10.1086\/323459"},{"key":"S0950268806007631_ref011","doi-asserted-by":"publisher","DOI":"10.1086\/504807"},{"key":"S0950268806007631_ref012","unstructured":"12.\u00a0Statistics Canada (http:\/\/www12.statcan.ca\/english\/profil01\/PlaceSearchForm1.cfm). 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