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Genotype<jats:italic>emm1<\/jats:italic>remained dominant throughout 2001 to 2005, but the frequency rate of this type decreased compared with the earlier period. Various other<jats:italic>emm<\/jats:italic>types have appeared in recent years indicating alterations in the prevalent strains causing severe invasive streptococcal infections. The cover of the new 26-valent GAS vaccine fell from 93\u00b75% for genotypes of isolates from 1996\u20132000 to 81\u00b78% in 2001\u20132005.<\/jats:p>","DOI":"10.1017\/s0950268807007984","type":"journal-article","created":{"date-parts":[[2007,2,9]],"date-time":"2007-02-09T04:23:22Z","timestamp":1170995002000},"page":"1227-1229","source":"Crossref","is-referenced-by-count":26,"title":["Distribution of<i>emm<\/i>genotypes among group A streptococcus isolates from patients with severe invasive streptococcal infections in Japan, 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