{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:30:30Z","timestamp":1792276230487,"version":"4.4.0"},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T00:00:00Z","timestamp":1173052800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The prevalence, incidence and outcomes of haemolytic uraemic syndrome (HUS) and thrombotic thrombocytopaenic purpura (TTP) are not well established in adults or children from prospective studies. We sought to identify both outcomes and current management strategies using prospective, national surveillance of HUS and TTP, from 2003 to 2005 inclusive. We also investigated the links between these disorders and factors implicated in the aetiology of HUS and TTP including infections, chemotherapy, and immunosuppression. Most cases of HUS were caused by verocytotoxin-producing<jats:italic>Escherichia coli<\/jats:italic>(VTEC), of which serotype O157 predominated, although other serotypes were identified. The list of predisposing factors for TTP was more varied although use of immunosuppressive agents and severe sepsis, were the most frequent precipitants. The study demonstrates that while differentiating between HUS and TTP is sometimes difficult, in most cases the two syndromes have quite different predisposing factors and clinical parameters, enabling clinical and epidemiological profiling for these disorders.<\/jats:p>","DOI":"10.1017\/s0950268807008217","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T11:13:49Z","timestamp":1173093229000},"page":"115-121","source":"Crossref","is-referenced-by-count":19,"title":["Clinical surveillance of thrombotic microangiopathies in Scotland, 2003\u20132005"],"prefix":"10.1017","volume":"136","author":[{"given":"K.\u00a0G.\u00a0J.","family":"POLLOCK","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"YOUNG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.\u00a0J.","family":"BEATTIE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.\u00a0T.\u00a0A.","family":"TODD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2007,3,5]]},"reference":[{"key":"S0950268807008217_ref020","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000109253.66918.5E"},{"key":"S0950268807008217_ref021","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050442"},{"key":"S0950268807008217_ref018","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-01-0193"},{"key":"S0950268807008217_ref012","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-0968.2003.00127.x"},{"key":"S0950268807008217_ref005","doi-asserted-by":"publisher","DOI":"10.3201\/eid1104.040833"},{"key":"S0950268807008217_ref007","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811263392202"},{"key":"S0950268807008217_ref013","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1182\/asheducation-2004.1.407","article-title":"Recent advances in thrombotic thrombocytopaenic purpura","author":"Sadler","year":"2004","journal-title":"Hematology (American Society of Hematology Education Program)"},{"key":"S0950268807008217_ref022","first-page":"109","article-title":"Hemolytic uremic syndrome in childhood: renal function ten years later","volume":"29","author":"Van Dyck","year":"1988","journal-title":"Clinical Nephrology"},{"key":"S0950268807008217_ref003","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.10.1360"},{"key":"S0950268807008217_ref015","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2236"},{"key":"S0950268807008217_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80482-2"},{"key":"S0950268807008217_ref023","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.303.6801.489"},{"key":"S0950268807008217_ref010","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1987.206"},{"key":"S0950268807008217_ref006","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811263392203"},{"key":"S0950268807008217_ref024","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.050581"},{"key":"S0950268807008217_ref019","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108083250605"},{"key":"S0950268807008217_ref016","first-page":"S89","article-title":"Thrombotic thrombocytopenic purpura: from platelet aggregates to plasma","volume":"121","author":"Marques","year":"2004","journal-title":"American Journal of Clinical Pathology"},{"key":"S0950268807008217_ref009","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200105000-00008"},{"key":"S0950268807008217_ref004","first-page":"1073","article-title":"Shiga toxin-producing Escherichia coli and the haemolytic uraemic syndrome","volume":"365","author":"Tarr","year":"2005","journal-title":"Lancet"},{"key":"S0950268807008217_ref017","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006293422601"},{"key":"S0950268807008217_ref014","doi-asserted-by":"publisher","DOI":"10.1136\/vr.157.22.697"},{"key":"S0950268807008217_ref011","doi-asserted-by":"crossref","first-page":"834","DOI":"10.5858\/2003-127-834-TTPAHU","article-title":"Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome are distinct pathologic entities. 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