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Since 2000, the E-test has been performed to determine ciprofloxacin minimum inhibitory concentrations of nalidixic acid-resistant isolates. The proportion of multi-resistant strains (resistant to \u2a7e4 antimicrobials) was highest among isolates from China and India, but is increasing significantly in other parts of Asia. Resistance to nalidixic acid has become common among the strains from the Far East, and the first isolates also resistant to ciprofloxacin were detected during 2004\u20132005. All the ciprofloxacin-resistant isolates belonged to the<jats:italic>S. flexneri<\/jats:italic>2a serotype. All the nalidixic acid-resistant<jats:italic>S. flexneri<\/jats:italic>strains had reduced susceptibility to ciprofloxacin, whereas 23% of the nalidixic acid-resistant<jats:italic>S. sonnei<\/jats:italic>strains were still completely susceptible to ciprofloxacin.<\/jats:p>","DOI":"10.1017\/s0950268807008862","type":"journal-article","created":{"date-parts":[[2007,6,20]],"date-time":"2007-06-20T08:41:25Z","timestamp":1182328885000},"page":"476-482","source":"Crossref","is-referenced-by-count":12,"title":["Emerging resistance to newer antimicrobial agents among<i>Shigella<\/i>isolated from Finnish foreign travellers"],"prefix":"10.1017","volume":"136","author":[{"given":"K.","family":"HAUKKA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"SIITONEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,6,20]]},"reference":[{"key":"S0950268807008862_ref029","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg080"},{"key":"S0950268807008862_ref010","unstructured":"10.\u00a0CLSI. 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