{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:18:15Z","timestamp":1761862695966},"reference-count":41,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2007,7,30]],"date-time":"2007-07-30T00:00:00Z","timestamp":1185753600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p><jats:italic>Neisseria meningitidis<\/jats:italic>is an important cause of childhood meningitis and septicaemia. Between 1999 and 2005, 133 invasive meningococcal disease (IMD) cases occurred in Jerusalem, 112 (84\u00b72%) of them in children aged 0\u201314 years. The annual incidence rate in Jerusalem was higher than the national average (2\u00b745\u00b10\u00b76<jats:italic>vs<\/jats:italic>. 1\u00b713\u00b10\u00b716\/100 000 population,<jats:italic>P<\/jats:italic>=0\u00b7002). Most of the children (82\u00b71%) were from low socio-economic Arab and Jewish ultra-orthodox communities; mortality was higher among Arab than Jewish children (1\u00b73<jats:italic>vs<\/jats:italic>. 0\u00b722\/100 000 person-years,<jats:italic>P<\/jats:italic>=0\u00b7004). A cluster of 10 children with severe meningococcal sepsis (three fatalities) emerged in the winter of 2003\u20132004. Compared to the other 102 cases in 1999\u20132005 both meningococcaemia (100%<jats:italic>vs<\/jats:italic>. 51%,<jats:italic>P<\/jats:italic>=0\u00b7003) and mortality (30%<jats:italic>vs<\/jats:italic>. 6\u00b79%,<jats:italic>P<\/jats:italic>=0\u00b7014) rates were higher. Serogroup B comprised 77\u00b76% of the bacterial isolates. Pulsed-field gel electrophoresis showed considerable variability among cluster isolates, but significant resemblance in Arab cases throughout 1999\u20132005. The increased susceptibility of specific sub-populations to IMD necessitates further evaluation.<\/jats:p>","DOI":"10.1017\/s0950268807009259","type":"journal-article","created":{"date-parts":[[2007,7,30]],"date-time":"2007-07-30T10:52:48Z","timestamp":1185792768000},"page":"782-789","source":"Crossref","is-referenced-by-count":18,"title":["Invasive meningococcal disease in children in Jerusalem"],"prefix":"10.1017","volume":"136","author":[{"given":"C.","family":"STEIN-ZAMIR","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"ABRAMSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"ZENTNER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"SHOOB","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"VALINSKY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"BLOCK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,7,30]]},"reference":[{"key":"S0950268807009259_ref026","doi-asserted-by":"publisher","DOI":"10.1007\/BF01739006"},{"key":"S0950268807009259_ref021","unstructured":"21.\u00a0Central Bureau of Statistics. Statistical Abstract of Israel 2005-No.56. Chapter 2. Population. Table 2.7 Localities and population by district, sub-district, area, population group and religion. State of Israel. Central Bureau of Statistics. Jerusalem 2005."},{"key":"S0950268807009259_ref024","doi-asserted-by":"publisher","DOI":"10.1186\/1742-5573-1-6"},{"key":"S0950268807009259_ref040","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.5.12.1611"},{"key":"S0950268807009259_ref039","doi-asserted-by":"crossref","first-page":"573","DOI":"10.5694\/j.1326-5377.2002.tb04586.x","article-title":"The control of meningococcal disease","volume":"176","author":"Hall","year":"2002","journal-title":"Medical Journal of Australia"},{"key":"S0950268807009259_ref020","unstructured":"20.\u00a0Ministry of Health, Israel. Weekly Epidemiological Reports 1999\u20132005, Department of Epidemiology, Public Health Services, Ministry of Health, Israel (http:\/\/www.health.gov.il)."},{"key":"S0950268807009259_ref030","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268805004553"},{"key":"S0950268807009259_ref035","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.4.1699-1705.2005"},{"key":"S0950268807009259_ref022","unstructured":"22.\u00a0Statistical Yearbook of Jerusalem 2005. Choshen M, ed. Chapter III, Population Table III\/12\u00a0\u2013\u00a0Population of Jerusalem, by Population Group and Age, 1997\u20132003. Jerusalem, 2005."},{"key":"S0950268807009259_ref038","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.01.061"},{"key":"S0950268807009259_ref031","first-page":"21","article-title":"Laboratory-Based Surveillance for Meningococcal Disease in Selected Areas, United States, 1989\u20131991","volume":"42","author":"Jackson","year":"1993","journal-title":"Morbidity and Mortality Weeekly Report. 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