{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:33:42Z","timestamp":1762004022639},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2007,8,3]],"date-time":"2007-08-03T00:00:00Z","timestamp":1186099200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Choline-binding proteins (CBP) have been associated with the pathogenesis of <jats:italic>Streptococcus pneumoniae<\/jats:italic>. We screened, using PCR, for the presence of genes (<jats:italic>cbpA, D, E, G<\/jats:italic>) encoding these proteins in 34 isolates of pneumococci of known serotypes and penicillin susceptibility from invasive and non-invasive disease. All isolates harboured <jats:italic>cbpD<\/jats:italic> and <jats:italic>cbpE<\/jats:italic> whereas <jats:italic>cbpA<\/jats:italic> and <jats:italic>cbpG<\/jats:italic> were found in 47% and 59% respectively; the latter were more frequent in vaccine-associated types and together accounted for 77% of these isolates. No association was observed with penicillin susceptibility but 85% of non-invasive isolates were positive for these genes.<\/jats:p>","DOI":"10.1017\/s0950268807009363","type":"journal-article","created":{"date-parts":[[2007,8,3]],"date-time":"2007-08-03T12:36:44Z","timestamp":1186144604000},"page":"940-942","source":"Crossref","is-referenced-by-count":10,"title":["Distribution of CBP genes in <i>Streptococcus pneumoniae<\/i> isolates in relation to vaccine types, penicillin susceptibility and clinical site"],"prefix":"10.1017","volume":"136","author":[{"given":"M.\u00a0N.","family":"DESA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u00a0D.","family":"SEKARAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"VADIVELU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"PARASAKTHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,8,3]]},"reference":[{"key":"S0950268807009363_ref005","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.6.1575-1577.2000"},{"key":"S0950268807009363_ref003","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.10.5690-5695.2000"},{"key":"S0950268807009363_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(01)02207-7"},{"key":"S0950268807009363_ref008","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-6-71"},{"key":"S0950268807009363_ref004","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03764.x"},{"key":"S0950268807009363_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/S1201-9712(03)90051-8"},{"key":"S0950268807009363_ref007","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/171.2.479"},{"key":"S0950268807009363_ref010","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.2.821-829.2006"},{"key":"S0950268807009363_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2005.11.001"},{"key":"S0950268807009363_ref002","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-148-7-2045"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268807009363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T23:22:04Z","timestamp":1556666524000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268807009363\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,3]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S0950268807009363"],"URL":"https:\/\/doi.org\/10.1017\/s0950268807009363","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,3]]}}}