{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T03:01:29Z","timestamp":1774321289750,"version":"3.50.1"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2007,11,8]],"date-time":"2007-11-08T00:00:00Z","timestamp":1194480000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Newly developed interferon-gamma release assays have become commercially available to detect tuberculosis (TB) infection in adults. However, little is known about their performance in children. We compared test results between the QuantiFERON-TB<jats:sup>\u00ae<\/jats:sup> Gold test (QFT) and tuberculin skin test (TST) in young children living with pulmonary TB patients in Cambodia. Of 195 children tested with both QFT and TST, the TST-positive rate of 24% was significantly higher than the QFT-positive rate of 17%. The agreement between the test results was considerable (\u03ba-coefficient 0\u00b763). Positive rates increased from 6% to 32% for QFT and from 15% to 43% for TST, according to the sputum smear grades of the index cases. The presence of Bacille Calmette-Gu\u00e9rin (BCG) scars did not significantly affect the results of TST or QFT in a logistic regression analysis. In conclusion, QFT can be a substitute for TST in detecting latent TB infection in childhood contacts aged \u2a7d5 years, especially in those who may have a false-positive TST due to BCG vaccination or non-tuberculous mycobacterial infection.<\/jats:p>","DOI":"10.1017\/s0950268807009831","type":"journal-article","created":{"date-parts":[[2007,11,8]],"date-time":"2007-11-08T11:36:15Z","timestamp":1194521775000},"page":"1179-1187","source":"Crossref","is-referenced-by-count":55,"title":["Performance of an interferon-gamma release assay for diagnosing latent tuberculosis infection in children"],"prefix":"10.1017","volume":"136","author":[{"given":"K.","family":"OKADA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.\u00a0E.","family":"MAO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"MORI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"MIURA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"SUGIYAMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"YOSHIYAMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"MITARAI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"ONOZAKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"HARADA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"SAINT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.\u00a0S.","family":"KONG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.\u00a0M.","family":"CHHOUR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,11,8]]},"reference":[{"key":"S0950268807009831_ref003","first-page":"373","article-title":"Childhood tuberculosis: ending the neglect","volume":"6","author":"Stark","year":"2002","journal-title":"International Journal of Tuberculosis and Lung Disease"},{"key":"S0950268807009831_ref004","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/17.6.968"},{"key":"S0950268807009831_ref008","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.22.2756"},{"key":"S0950268807009831_ref025","first-page":"23","article-title":"Tuberculin reactivity in a pediatric population with high BCG vaccination coverage","volume":"3","author":"Lockman","year":"1999","journal-title":"International Journal of Tuberculosis and Lung Disease"},{"key":"S0950268807009831_ref015","first-page":"939","article-title":"Results of a tuberculosis-specific IFN- \u03b3 assay in children at high risk for tuberculosis infection","volume":"10","author":"Tsiouris","year":"2006","journal-title":"International Journal of Tuberculosis and Lung Disease"},{"key":"S0950268807009831_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12950-9"},{"key":"S0950268807009831_ref014","doi-asserted-by":"publisher","DOI":"10.3201\/eid1209.051606"},{"key":"S0950268807009831_ref023","first-page":"26","volume-title":"Epidemiological Basis of TB Control","author":"Rieder","year":"1999"},{"key":"S0950268807009831_ref005","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200402-179OC"},{"key":"S0950268807009831_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17592-2"},{"key":"S0950268807009831_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67534-4"},{"key":"S0950268807009831_ref020","unstructured":"20.\u00a0National Center for Tuberculosis and Leprosy Control, Cambodia. Technical Guidelines for Tuberculosis Control in Cambodia. Ministry of Health, Kingdom of Cambodia, 2003 [in Khmer]."},{"key":"S0950268807009831_ref009","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.22.2746"},{"key":"S0950268807009831_ref033","first-page":"1","article-title":"Targeted tuberculin testing and treatment of latent tuberculosis infection","volume":"49","year":"2000","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"S0950268807009831_ref002","first-page":"636","article-title":"Global epidemiology of childhood tuberculosis","volume":"8","author":"Nelson","year":"2004","journal-title":"International Journal of Tuberculosis and Lung Disease"},{"key":"S0950268807009831_ref030","first-page":"1","article-title":"Guidelines for the investigation of contacts of persons with infectious tuberculosis","volume":"54","year":"2005","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"S0950268807009831_ref019","first-page":"19","volume-title":"Treatment of Tuberculosis: Guidelines for National Programmes","year":"1997"},{"key":"S0950268807009831_ref006","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200402-232OC"},{"key":"S0950268807009831_ref032","unstructured":"32.\u00a0National Center for Tuberculosis and Leprosy Control, Cambodia.National HIV sero-prevalence survey amongst TB patients in Cambodia, 2005. Ministry of Health, Kingdom of Cambodia, 2006."},{"key":"S0950268807009831_ref021","unstructured":"21.\u00a0Nihon BCG Inc. (http:\/\/www.bcg-qft.com\/index.html) [in Japanese]. 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Ministry of Health, Kingdom of Cambodia, 2005."},{"key":"S0950268807009831_ref029","first-page":"1122","article-title":"Skin test reactions to Mycobacterium tuberculosis purified protein derivative and Mycobacterium avium sensitin among health care workers and medical students in the United State","volume":"5","author":"Von Reyn","year":"2001","journal-title":"International Journal of Tuberculosis and Lung Disease"},{"key":"S0950268807009831_ref031","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(84)90082-0"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268807009831","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T22:42:45Z","timestamp":1556664165000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268807009831\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,8]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["S0950268807009831"],"URL":"https:\/\/doi.org\/10.1017\/s0950268807009831","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,8]]}}}