{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T13:51:06Z","timestamp":1764078666502},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2008,6,18]],"date-time":"2008-06-18T00:00:00Z","timestamp":1213747200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>We performed a systematic review to estimate the effectiveness of vaccination, in addition to chemoprophylaxis, in preventing meningococcal disease among household contacts. Medline, EMBASE, EMGM, and EUIBIS were used for data collection. Studies reporting on at least 100 primary cases and on subsequent cases in household settings with follow-up of more than 2 weeks after onset of disease in the primary case were reviewed. A meta-analysis was used to calculate the average attack rate in household contacts given chemoprophylaxis 14\u2013365 days after onset of disease in the primary case. In total, 652 studies were identified, five studies and one unpublished report met the inclusion criteria. The weighted average attack rate was 1\u00b71\/1000 household contacts (95% CI 0\u00b77\u20131\u00b77). This review supports vaccination of household contacts in addition to chemoprophylaxis to reduce the risk of meningococcal disease among household contacts of a case caused by a vaccine-preventable serogroup.<\/jats:p>","DOI":"10.1017\/s0950268808000770","type":"journal-article","created":{"date-parts":[[2008,6,18]],"date-time":"2008-06-18T07:51:46Z","timestamp":1213775506000},"page":"1441-1447","source":"Crossref","is-referenced-by-count":13,"title":["Effectiveness of vaccinating household contacts in addition to chemoprophylaxis after a case of meningococcal disease: a systematic review"],"prefix":"10.1017","volume":"136","author":[{"given":"M.\u00a0R.","family":"HOEK","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"CHRISTENSEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"HELLENBRAND","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"STEFANOFF","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"HOWITZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u00a0M.","family":"STUART","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2008,6,18]]},"reference":[{"key":"S0950268808000770_ref028","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3180cc2c25"},{"key":"S0950268808000770_ref027","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16725-1"},{"key":"S0950268808000770_ref026","doi-asserted-by":"publisher","DOI":"10.3201\/eid1009.030992"},{"key":"S0950268808000770_ref025","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.031369"},{"key":"S0950268808000770_ref024","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6123.1317"},{"key":"S0950268808000770_ref023","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.85.6.843"},{"key":"S0950268808000770_ref022","unstructured":"22.\u00a0 Samuelsson S . Surveillance and prevention of meningococcal disease in Denmark 1980\u201396 (Ph.D. thesis). Faculty of Health Sciences, Southern Denmark, 1999."},{"key":"S0950268808000770_ref018","doi-asserted-by":"publisher","DOI":"10.2807\/ese.13.10.08059-en"},{"key":"S0950268808000770_ref017","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268899003775"},{"key":"S0950268808000770_ref016","first-page":"1505","article-title":"Secondary cases of meningococcal disease in the Netherlands, 1989\u20131990 A reappraisal of chemoprohylaxis","volume":"137","author":"Scholten","year":"1993","journal-title":"Nederlands Tijdschrift van de Geneeskunde"},{"key":"S0950268808000770_ref015","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1976.03260290019018"},{"key":"S0950268808000770_ref014","first-page":"195","article-title":"A retrospective survey of clusters of meningococcal disease in England and Wales, 1993 to 1995: estimated risks of further cases in household and educational settings","volume":"7","author":"Hastings","year":"1997","journal-title":"Communicable Disease Report Review"},{"key":"S0950268808000770_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2003.09.022"},{"key":"S0950268808000770_ref011","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6673.555"},{"key":"S0950268808000770_ref010","doi-asserted-by":"publisher","DOI":"10.1136\/jech.53.9.516"},{"key":"S0950268808000770_ref009","doi-asserted-by":"publisher","DOI":"10.2807\/ese.13.10.08060-en"},{"key":"S0950268808000770_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)90022-1"},{"key":"S0950268808000770_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(81)80009-6"},{"key":"S0950268808000770_ref003","doi-asserted-by":"publisher","DOI":"10.1086\/319595"},{"key":"S0950268808000770_ref021","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2003.11.052"},{"key":"S0950268808000770_ref008","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6673.569"},{"key":"S0950268808000770_ref006","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7452.1339"},{"key":"S0950268808000770_ref001","unstructured":"1.\u00a0 Ramsay M , Fox A , Chandra M . Invasive Neisseria meningitidis in Europe. European Union Invasive Bacterial Infectious Surveillance Network, 2003\u20132004 (http:\/\/www.euibis.org)."},{"key":"S0950268808000770_ref007","volume-title":"The Cochrane Library","author":"Fraser","year":"2005"},{"key":"S0950268808000770_ref002","first-page":"426","article-title":"Outcomes of meningococcal disease during the teenage peak","volume":"88","author":"Borg","year":"2003","journal-title":"Archives of Diseases in Childhood"},{"key":"S0950268808000770_ref013","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001093.pub2"},{"key":"S0950268808000770_ref020","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0167"},{"key":"S0950268808000770_ref019","first-page":"1","article-title":"Control and prevention of meningococcal disease and control and prevention of serogroup C meningococcal disease: evaluation and management of suspected outbreaks","volume":"46","year":"1997","journal-title":"Morbidity and Mortality Weekly Report"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268808000770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T21:54:30Z","timestamp":1556661270000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268808000770\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,18]]},"references-count":28,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S0950268808000770"],"URL":"https:\/\/doi.org\/10.1017\/s0950268808000770","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,18]]}}}