{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:16:13Z","timestamp":1791404173324,"version":"4.3.3"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2008,6,18]],"date-time":"2008-06-18T00:00:00Z","timestamp":1213747200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Diabetes mellitus (DM) is a known risk factor for pulmonary tuberculosis (PTB). This study aimed to determine if type 2 DM alters manifestations and treatment outcome of PTB. Records of 217 consecutive culture-proven PTB patients were analysed retrospectively. The manifestations and treatment outcomes of 74 patients with type 2 DM (PTB-DM group) were compared to 143 patients without DM (PTB group). PTB-DM patients showed higher frequencies of fever, haemoptysis, positive acid-fast bacilli sputum smears, and consolidation, cavity, and lower lung field lesions on chest radiographs, and higher mortality rate. Furthermore, type 2 DM, age \u2a7e65 years, and extensive radiographic disease were factors independently associated with an unfavorable outcome. This study confirmed that clinical manifestations and chest radiographs of PTB patients associated with type 2 DM significantly depart from the typical presentation. Type 2 DM seems to have a negative effect on treatment outcome of PTB.<\/jats:p>","DOI":"10.1017\/s0950268808000782","type":"journal-article","created":{"date-parts":[[2008,6,18]],"date-time":"2008-06-18T07:52:07Z","timestamp":1213775527000},"page":"203-210","source":"Crossref","is-referenced-by-count":104,"title":["Impact of type 2 diabetes on manifestations and treatment outcome of pulmonary tuberculosis"],"prefix":"10.1017","volume":"137","author":[{"given":"C. S.","family":"WANG","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. J.","family":"YANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. C.","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. H.","family":"CHUANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. W.","family":"CHONG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"HWANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"HUANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2008,6,18]]},"reference":[{"key":"S0950268808000782_ref029","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199120060-00004"},{"key":"S0950268808000782_ref028","doi-asserted-by":"publisher","DOI":"10.1086\/507543"},{"key":"S0950268808000782_ref026","doi-asserted-by":"publisher","DOI":"10.1007\/BF00270420"},{"key":"S0950268808000782_ref025","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0891-5520(20)30641-3","article-title":"Pulmonary complications of diabetes mellitus. Pneumonia","volume":"9","author":"Koziel","year":"1995","journal-title":"Infectious Disease Clinics of North America"},{"key":"S0950268808000782_ref021","first-page":"62","article-title":"Symptomatology and chest roentgenographic changes of pulmonary tuberculosis among diabetics","volume":"74","author":"al-Wabel","year":"1997","journal-title":"East African Medical Journal"},{"key":"S0950268808000782_ref020","doi-asserted-by":"publisher","DOI":"10.1159\/000050578"},{"key":"S0950268808000782_ref019","first-page":"213","article-title":"Tuberculosis in diabetic patients: a clinical perspective","volume":"36","author":"Nissapatorn","year":"2005","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"S0950268808000782_ref018","doi-asserted-by":"publisher","DOI":"10.1086\/519841"},{"key":"S0950268808000782_ref017","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-7-234"},{"key":"S0950268808000782_ref015","first-page":"80","article-title":"An epidemiological evaluation of risk factors for tuberculosis in South India: a matched case control study","volume":"10","author":"Shetty","year":"2006","journal-title":"International Journal of Tuberculosis and Lung Disease"},{"key":"S0950268808000782_ref005","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.7.1584"},{"key":"S0950268808000782_ref014","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268806006935"},{"key":"S0950268808000782_ref009","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.5.2001040"},{"key":"S0950268808000782_ref007","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.5.1047"},{"key":"S0950268808000782_ref006","doi-asserted-by":"publisher","DOI":"10.1177\/1742395307081502"},{"key":"S0950268808000782_ref001","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.22.2767"},{"key":"S0950268808000782_ref013","unstructured":"13. WHO. Global tuberculosis control: surveillance, planning, financing. WHO report, 2006. Geneva, World Health Organization (WHO\/HTM\/TB\/2006.362). (http:\/\/www.who.int\/tb\/publications\/global_report\/2006\/pdf\/full_report.pdf). Accessed 1 December 2007."},{"key":"S0950268808000782_ref031","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.1976.11716533"},{"key":"S0950268808000782_ref030","doi-asserted-by":"publisher","DOI":"10.1086\/429321"},{"key":"S0950268808000782_ref016","first-page":"74","article-title":"Influence of diabetes on manifestations and treatment outcome of pulmonary TB patients","volume":"10","author":"Singla","year":"2006","journal-title":"International Journal of Tuberculosis and Lung Disease"},{"key":"S0950268808000782_ref011","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.96.09051097"},{"key":"S0950268808000782_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/0041-3879(90)90040-F"},{"key":"S0950268808000782_ref010","first-page":"278","article-title":"Does diabetes alter the radiological presentation of pulmonary tuberculosis","volume":"24","author":"Shaikh","year":"2003","journal-title":"Saudi Medical Journal"},{"key":"S0950268808000782_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/0962-8479(95)90529-4"},{"key":"S0950268808000782_ref012","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.143.3.509"},{"key":"S0950268808000782_ref008","first-page":"455","article-title":"Atypical radiological images of pulmonary tuberculosis in 192 diabetic patients: a comparative study","volume":"5","author":"Perez-Guzman","year":"2001","journal-title":"International Journal of Tuberculosis and Lung Disease"},{"key":"S0950268808000782_ref022","first-page":"777","article-title":"Factors changing the manifestation of pulmonary tuberculosis","volume":"9","author":"Wang","year":"2005","journal-title":"International Journal of Tuberculosis and Lung Disease"},{"key":"S0950268808000782_ref002","first-page":"696","article-title":"Diabetes mellitus is strongly associated with tuberculosis in Indonesia","volume":"10","author":"Alisjahbana","year":"2006","journal-title":"International Journal of Tuberculosis and Lung Disease"},{"key":"S0950268808000782_ref024","first-page":"162","article-title":"Unusual radiographic presentation of pulmonary tuberculosis in diabetic patients","volume":"109","author":"Weaver","year":"1974","journal-title":"American Review of Respiratory Disease"},{"key":"S0950268808000782_ref023","doi-asserted-by":"publisher","DOI":"10.1016\/0007-0971(83)90010-4"},{"key":"S0950268808000782_ref027","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/142.6.869"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268808000782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T06:30:32Z","timestamp":1631428232000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268808000782\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,18]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0950268808000782"],"URL":"https:\/\/doi.org\/10.1017\/s0950268808000782","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,18]]}}}