{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:43:26Z","timestamp":1790243006395,"version":"4.1.0"},"reference-count":11,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2008,7,31]],"date-time":"2008-07-31T00:00:00Z","timestamp":1217462400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p><jats:italic>Neisseria meningitidis<\/jats:italic>capsular switching has been reported in several countries. In order to establish the genetic relationship within group B and C strains expressing subtypes 2a or 2b, and to evaluate whether C to B capsular switching occurred in Portugal, 64 meningococci (56 serogroup C and 8 serogroup B) isolated from invasive meningococcal disease were typed using molecular methods. The studied phenotypes, 2b:P1.5,2 and 2a:P1.5-1,10-8, were the most frequent among serogroup C, but were uncommon among serogroup B strains. The multi-locus sequence typing (MLST) allelic profile and the pulsed-field gel electrophoresis (PFGE) fingerprints showed that seven serogroup B strains were genotypically identical to C strains, suggesting that capsular switching occurred. Active laboratory surveillance to find evidence of capsule switching is a now priority as MenC was introduced in the Portuguese vaccination schedule in January 2006.<\/jats:p>","DOI":"10.1017\/s0950268808001106","type":"journal-article","created":{"date-parts":[[2008,7,31]],"date-time":"2008-07-31T10:57:33Z","timestamp":1217501853000},"page":"161-165","source":"Crossref","is-referenced-by-count":22,"title":["Molecular surveillance of<i>Neisseria meningitidis<\/i>capsular switching in Portugal, 2002\u20132006"],"prefix":"10.1017","volume":"137","author":[{"given":"M. J.","family":"SIM\u00d5ES","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"CUNHA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"ALMEIDA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"FURTADO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"BRUM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2008,7,31]]},"reference":[{"key":"S0950268808001106_ref011","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.55.1.561"},{"key":"S0950268808001106_ref007","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1987.tb02626.x"},{"key":"S0950268808001106_ref005","doi-asserted-by":"publisher","DOI":"10.1086\/517439"},{"key":"S0950268808001106_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-2508(99)80052-7"},{"key":"S0950268808001106_ref003","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.12.5783-5786.2003"},{"key":"S0950268808001106_ref002","doi-asserted-by":"publisher","DOI":"10.3201\/eid0812.020081"},{"key":"S0950268808001106_ref001","unstructured":"1. General Health Department and National Institute of Health Dr. Ricardo Jorge Report. Meningococcal disease in Portugal 2000\u20132006. DGS and INSA, 2007, pp. 16\u201317."},{"key":"S0950268808001106_ref006","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.1.271"},{"key":"S0950268808001106_ref010","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1128\/JCM.33.9.2233-2239.1995","article-title":"Interpreting chromosomal DNA restriction patterns produced by bacterial strains typing","volume":"33","author":"Tenover","year":"1995","journal-title":"Journal of Clinical Microbiology"},{"key":"S0950268808001106_ref008","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.12.4531-4535.2002"},{"key":"S0950268808001106_ref009","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.6.3140"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268808001106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T10:57:06Z","timestamp":1588849026000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268808001106\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,31]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0950268808001106"],"URL":"https:\/\/doi.org\/10.1017\/s0950268808001106","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,31]]}}}