{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:21:46Z","timestamp":1789849306896,"version":"4.0.1"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2008,10,8]],"date-time":"2008-10-08T00:00:00Z","timestamp":1223424000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Infection with Epstein\u2013Barr virus (EBV) followed by infectious mononucleosis (IM) is now considered to be a risk factor for Hodgkin's disease (HD). It is less clear whether EBV infection and IM are associated with an increased risk of cancer generally. We used a longstanding record-linkage dataset in Oxford (years 1963\u20131998), and a more recent record-linkage dataset covering England (1999\u20132005), to compare rate ratios for cancer between people admitted to hospital for IM and a reference cohort. In the Oxford cohort, there was an increased risk of subsequent HD [rate ratio (RR) 6\u00b70, 95% confidence interval (CI) 2\u00b74\u201312\u00b75] but not of other cancers combined (RR 0\u00b785, 95% CI 0\u00b757\u20131\u00b723). In the England cohort, there were increased risks of HD (RR 3\u00b72, 95% CI 1\u00b72\u20137\u00b70), non-Hodgkin's lymphoma (RR 5\u00b76, 95% CI 2\u00b79\u20139\u00b78), and oropharyngeal cancer (RR 5\u00b74, 95% CI 1\u00b71\u201316\u00b72), but no significant overall risk of cancer when lymphomas were excluded (RR 1\u00b701, 95% CI 0\u00b771\u20131\u00b741). We confirm an association between IM and lymphoma; but the risk, if any, of cancer more generally is likely to be small.<\/jats:p>","DOI":"10.1017\/s0950268808001246","type":"journal-article","created":{"date-parts":[[2008,10,8]],"date-time":"2008-10-08T09:10:49Z","timestamp":1223457049000},"page":"672-680","source":"Crossref","is-referenced-by-count":20,"title":["Associations between infectious mononucleosis and cancer: record-linkage studies"],"prefix":"10.1017","volume":"137","author":[{"given":"M. J.","family":"GOLDACRE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. J.","family":"WOTTON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. G. R.","family":"YEATES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2008,10,8]]},"reference":[{"key":"S0950268808001246_ref017","doi-asserted-by":"publisher","DOI":"10.1007\/s102380200019"},{"key":"S0950268808001246_ref018","first-page":"1254","volume-title":"The Causes of Cancer","author":"Doll","year":"1981"},{"key":"S0950268808001246_ref006","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/93.10.669"},{"key":"S0950268808001246_ref008","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602511"},{"key":"S0950268808001246_ref010","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.187.4.334"},{"key":"S0950268808001246_ref014","doi-asserted-by":"publisher","DOI":"10.1136\/jech.54.6.431"},{"key":"S0950268808001246_ref005","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1452"},{"key":"S0950268808001246_ref007","unstructured":"7. Goldacre M , Gill L . Linkage of hospital episode statistics in England: opportunities for public health. London: Faculty of Public Health (http:\/\/www.fph.org.uk\/resources\/newsletters\/phcom\/archive\/2005\/phcom_dec05.pdf). Accessed 11 March 2008."},{"key":"S0950268808001246_ref011","first-page":"93","volume-title":"Statistical Methods in Cancer Research, Volume II. The Design and Analysis of Cohort Studies","author":"Breslow","year":"1987"},{"key":"S0950268808001246_ref009","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602392"},{"key":"S0950268808001246_ref004","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3566"},{"key":"S0950268808001246_ref015","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1054\/bjoc.1999.1049","article-title":"Risk factors for Hodgkin's disease by Epstein Barr virus (EBV) status: prior infection by EBV and other agents","volume":"82","author":"Alexander","year":"2000","journal-title":"British Journal of Cancer"},{"key":"S0950268808001246_ref016","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa023141"},{"key":"S0950268808001246_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66780-3"},{"key":"S0950268808001246_ref013","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.18.1522"},{"key":"S0950268808001246_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/S1040-8428(00)00046-9"},{"key":"S0950268808001246_ref002","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5913.253"},{"key":"S0950268808001246_ref012","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.95103s8259"},{"key":"S0950268808001246_ref001","first-page":"3568","volume-title":"Oxford Textbook Medicine","author":"Bunch","year":"1996"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268808001246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T17:37:04Z","timestamp":1556645824000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268808001246\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,8]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S0950268808001246"],"URL":"https:\/\/doi.org\/10.1017\/s0950268808001246","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,8]]}}}