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However, this opinion was based on a study of one isolate of LBV only and the reduction in pathogenicity was essentially attributed to the amino-acid substitution at position 333 of glycoprotein ectodomain. In the present study we have demonstrated that peripheral pathogenicity of representatives of LBV in a murine model is as high as that of RABV. Comparison of amino-acid substitutions among the viral glycoproteins, demonstrated significant differences within two antigenic sites between different phylogenetic lineages of LBV. Such molecular variability potentially contributes to differences in peripheral pathogenicity of lyssaviruses.<\/jats:p>","DOI":"10.1017\/s0950268808001945","type":"journal-article","created":{"date-parts":[[2009,1,15]],"date-time":"2009-01-15T10:49:44Z","timestamp":1232016584000},"page":"1155-1162","source":"Crossref","is-referenced-by-count":26,"title":["Lagos bat virus virulence in mice inoculated by the peripheral route"],"prefix":"10.1017","volume":"137","author":[{"given":"W.","family":"MARKOTTER","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. V.","family":"KUZMIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. E.","family":"RUPPRECHT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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