{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:15:00Z","timestamp":1760015700912},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2009,2,26]],"date-time":"2009-02-26T00:00:00Z","timestamp":1235606400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p><jats:italic>In vitro<\/jats:italic> tests have been developed for the diagnosis of tuberculosis (TB) infection. The objective was to analyse latent TB infection in drug and alcohol abusers through two interferon-\u03b3 techniques. One hundred and thirty-nine patients were admitted between February 2006 and May 2007. Mean age was 39\u00b78 years [31% HIV positive]. The enzyme immunoassay (EIA) and enzyme-linked immunospot (ELISPOT) interferon-\u03b3 assays were positive in 34% of patients with an agreement of 83% (\u03ba=0\u00b763). Tuberculin skin test (TST) was positive in 29% of patients and the agreement of TST with EIA and ELISPOT interferon-\u03b3 assays was 85% (\u03ba=0\u00b762) and 83% (\u03ba=0\u00b757), respectively. Almost 50% of patients with history of TB had a positive <jats:italic>in vitro<\/jats:italic> test. In conclusion, we observed a high prevalence of latent TB and good agreement between the new <jats:italic>in vitro<\/jats:italic> tests that otherwise may continue to be positive long after developing TB disease.<\/jats:p>","DOI":"10.1017\/s0950268809002131","type":"journal-article","created":{"date-parts":[[2009,2,26]],"date-time":"2009-02-26T09:42:26Z","timestamp":1235641346000},"page":"1342-1347","source":"Crossref","is-referenced-by-count":11,"title":["Prospective evaluation of latent tuberculosis with interferon-\u03b3 release assays in drug and alcohol abusers"],"prefix":"10.1017","volume":"137","author":[{"given":"I.","family":"RIVAS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"LATORRE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"SANVISENS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"DOM\u00cdNGUEZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"TOR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"PRAT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"REY-JOLY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"MUGA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,2,26]]},"reference":[{"key":"S0950268809002131_ref020","first-page":"1183","article-title":"Tuberculosis infection in drug users: interferon-gamma release assay performance","volume":"11","author":"Grimes","year":"2007","journal-title":"International Journal of Tuberculosis and Lung Disease"},{"key":"S0950268809002131_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(95)90649-5"},{"key":"S0950268809002131_ref018","doi-asserted-by":"publisher","DOI":"10.1086\/314707"},{"key":"S0950268809002131_ref019","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-6-47"},{"key":"S0950268809002131_ref005","first-page":"430","article-title":"Clinical and epidemiological aspects of smoking and tuberculosis: a study of 13 083 cases","volume":"4","author":"Altet-Gomez","year":"2005","journal-title":"International Journal of Tuberculosis and Lung Disease"},{"key":"S0950268809002131_ref004","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199603283341304"},{"key":"S0950268809002131_ref021","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68579-6"},{"key":"S0950268809002131_ref023","doi-asserted-by":"publisher","DOI":"10.1309\/LTETF72AHG94KGUY"},{"key":"S0950268809002131_ref012","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200509-1516PP"},{"key":"S0950268809002131_ref007","unstructured":"7. National Register of AIDS cases. Carlos III Health Institute, National Epidemiology Center, Secretariat of the National Plan of AIDS. HIV\/AIDS epidemiological surveillance in Spain. Updated to December 2006. Semester Report no. 2, 2006."},{"key":"S0950268809002131_ref002","first-page":"295","article-title":"Tuberculosis in Spain: epidemiological pattern and clinical practice","volume":"6","author":"D\u00edez","year":"2002","journal-title":"International Journal of Tuberculosis and Lung Disease"},{"key":"S0950268809002131_ref006","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-119-3-199308010-00003"},{"key":"S0950268809002131_ref001","unstructured":"1. Euro TB and the national coordinators for tuberculosis in the WHO European Region. Surveillance of tuberculosis in Europe. Report on tuberculosis cases notified in 2005. Institut de Veille Sanitaire, Saint Maurice, France, March 2007 (http:\/\/www.eurotb.org). 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