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In the NORMAT study (126 individuals randomly sampled from the general population) 24 (19%) were positive for<jats:italic>Blastocystis<\/jats:italic>.<jats:italic>Blastocystis<\/jats:italic>was associated with irritable bowel syndrome (<jats:italic>P<\/jats:italic>=0\u00b704), contact with pigs (<jats:italic>P<\/jats:italic>&lt;0\u00b701) and poultry (<jats:italic>P<\/jats:italic>=0\u00b703). In the Follow-up (FU) study (follow-up of 92<jats:italic>Blastocystis<\/jats:italic>-positive patients), reports on bloating were associated with subtype (ST) 2 (<jats:italic>P<\/jats:italic>&lt;0\u00b701), and blood in stool to mixed subtype infection (<jats:italic>P<\/jats:italic>=0\u00b706). ST1 was more common in FU individuals (32%) than in NORMAT individuals (8%), whereas single subtype infections due to ST3 or ST4 were seen in 63% of the NORMAT cases and 28% of the FU cases. Only FU individuals hosted ST7, and ST6\/7 infections due to ST7 or ST9 were characterized by multiple intestinal symptoms. The data indicate subtype-dependent differences in the clinical significance of<jats:italic>Blastocystis<\/jats:italic>.<\/jats:p>","DOI":"10.1017\/s0950268809002672","type":"journal-article","created":{"date-parts":[[2009,4,27]],"date-time":"2009-04-27T10:08:51Z","timestamp":1240826931000},"page":"1655-1663","source":"Crossref","is-referenced-by-count":159,"title":["<i>Blastocystis<\/i>: unravelling potential risk factors and clinical significance of a common but neglected parasite"],"prefix":"10.1017","volume":"137","author":[{"given":"C. R.","family":"STENSVOLD","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. C.","family":"LEWIS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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