{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:49:38Z","timestamp":1791118178123,"version":"4.1.0"},"reference-count":41,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2009,6,16]],"date-time":"2009-06-16T00:00:00Z","timestamp":1245110400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Due to its extensive polymorphism, a partial sequence of the<jats:italic>Cryptosporidium<\/jats:italic>surface glycoprotein gene gp60 has been frequently used as a genetic marker. I explored the global diversity of this protein, and compared its sequence diversity in<jats:italic>Cryptosporidium parvum<\/jats:italic>and<jats:italic>Cryptosporidium hominis<\/jats:italic>. In marked contrast to the geographical partition of<jats:italic>C. parvum<\/jats:italic>and<jats:italic>C. hominis<\/jats:italic>multi-locus genotypes, gp60 allelic groups showed no evidence of segregating in space, or of differing with respect to geographical diversity. Globally, genetic diversity of<jats:italic>C. hominis<\/jats:italic>gp60 exceeded that of<jats:italic>C. parvum<\/jats:italic>. Within<jats:italic>C. parvum<\/jats:italic>, gp60 alleles originating from human isolates were more diverse than those infecting ruminants. Phylogenetic analysis grouped gp60 sequences into a small number of relatively homogenous allelic groups, with only a small number of alleles having evolved independently. With the notable exception of a group of alleles restricted to humans,<jats:italic>C. parvum<\/jats:italic>alleles are found in ruminants and humans.<\/jats:p>","DOI":"10.1017\/s0950268809990215","type":"journal-article","created":{"date-parts":[[2009,6,16]],"date-time":"2009-06-16T09:22:25Z","timestamp":1245144145000},"page":"1800-1808","source":"Crossref","is-referenced-by-count":35,"title":["Meta-analysis of a polymorphic surface glycoprotein of the parasitic protozoa<i>Cryptosporidium parvum<\/i>and<i>Cryptosporidium hominis<\/i>"],"prefix":"10.1017","volume":"137","author":[{"given":"G.","family":"WIDMER","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2009,6,16]]},"reference":[{"key":"S0950268809990215_ref013","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.7.3881-3890.2002"},{"key":"S0950268809990215_ref028","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.2002.tb00224.x"},{"key":"S0950268809990215_ref012","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01576-08"},{"key":"S0950268809990215_ref032","doi-asserted-by":"publisher","DOI":"10.1016\/0025-5564(81)90086-9"},{"key":"S0950268809990215_ref004","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.72.4.2507-2513.2006"},{"key":"S0950268809990215_ref031","doi-asserted-by":"publisher","DOI":"10.1046\/j.1461-0248.2001.00230.x"},{"key":"S0950268809990215_ref035","first-page":"406","article-title":"The neighbor-joining method: a new method for reconstructing phylogenetic trees","volume":"4","author":"Saitou","year":"1987","journal-title":"Molecular Biology and Evolution"},{"key":"S0950268809990215_ref025","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-003-0834-5"},{"key":"S0950268809990215_ref021","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268808000769"},{"key":"S0950268809990215_ref027","first-page":"645","article-title":"Multilocus genetic analysis of Cryptosporidium isolates from Saudi Arabia","volume":"38","author":"Al-Brikan","year":"2008","journal-title":"Journal of the Egyptian Society of Parasitology"},{"key":"S0950268809990215_ref014","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01590-06"},{"key":"S0950268809990215_ref018","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182007003460"},{"key":"S0950268809990215_ref007","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.7.4117-4134.2000"},{"key":"S0950268809990215_ref002","doi-asserted-by":"publisher","DOI":"10.1038\/nature02977"},{"key":"S0950268809990215_ref041","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/genetics\/149.1.189","article-title":"Genetic polymorphism and natural selection in the malaria parasite Plasmodium falciparum","volume":"149","author":"Escalante","year":"1998","journal-title":"Genetics"},{"key":"S0950268809990215_ref036","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msm092"},{"key":"S0950268809990215_ref011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05594.x"},{"key":"S0950268809990215_ref003","doi-asserted-by":"publisher","DOI":"10.1007\/s00239-002-2412-3"},{"key":"S0950268809990215_ref015","doi-asserted-by":"publisher","DOI":"10.3201\/eid1301.060481"},{"key":"S0950268809990215_ref020","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.6.2744-2747.2003"},{"key":"S0950268809990215_ref029","first-page":"95","article-title":"BioEdit, a user-friendly biological sequence alignment editor and analysis program for Windows 95\/98\/NT","volume":"41","author":"Hall","year":"1999","journal-title":"Nucleic Acids Symposium Series"},{"key":"S0950268809990215_ref033","doi-asserted-by":"publisher","DOI":"10.1038\/163688a0"},{"key":"S0950268809990215_ref040","doi-asserted-by":"publisher","DOI":"10.3201\/eid1405.071277"},{"key":"S0950268809990215_ref034","volume-title":"Measuring Biolocial Diversity","author":"Magurran","year":"2004"},{"key":"S0950268809990215_ref008","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.7.4108-4116.2000"},{"key":"S0950268809990215_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(01)00393-0"},{"key":"S0950268809990215_ref001","doi-asserted-by":"publisher","DOI":"10.1126\/science.1094786"},{"key":"S0950268809990215_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2006.08.006"},{"key":"S0950268809990215_ref024","doi-asserted-by":"publisher","DOI":"10.3201\/eid1410.071273"},{"key":"S0950268809990215_ref037","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btg359"},{"key":"S0950268809990215_ref009","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.6.2805-2809.2005"},{"key":"S0950268809990215_ref016","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182006001508"},{"key":"S0950268809990215_ref039","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.9.5167-5175.2000"},{"key":"S0950268809990215_ref038","first-page":"418","article-title":"Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions","volume":"3","author":"Nei","year":"1986","journal-title":"Molecular Biology and Evolution"},{"key":"S0950268809990215_ref022","doi-asserted-by":"publisher","DOI":"10.3201\/eid0304.970423"},{"key":"S0950268809990215_ref019","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00116-08"},{"key":"S0950268809990215_ref023","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00936-08"},{"key":"S0950268809990215_ref026","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.2.589-591.2006"},{"key":"S0950268809990215_ref017","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-006-0337-2"},{"key":"S0950268809990215_ref030","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/22.22.4673"},{"key":"S0950268809990215_ref006","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182099005508"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268809990215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T11:23:14Z","timestamp":1633605794000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268809990215\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,16]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0950268809990215"],"URL":"https:\/\/doi.org\/10.1017\/s0950268809990215","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,16]]}}}