{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:19:39Z","timestamp":1789654779495,"version":"4.0.1"},"reference-count":32,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,6,19]],"date-time":"2009-06-19T00:00:00Z","timestamp":1245369600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Invasive pneumococcal disease (IPD) is of concern in Japan, where the heptavalent pneumococcal conjugate vaccine (PCV7) is unavailable. We determined serotypes, genotypes indicating \u03b2-lactam resistance, and antibiotic susceptibilities of 496 isolates from normally sterile sites in patients (193 children, 303 adults) from 186 institutions between August 2006 and July 2007. Disease presentations included sepsis (46\u00b72%), pneumonia (31\u00b75%), and meningitis (17\u00b75%). Mortality was 1\u00b74% in children and 22\u00b71% in adults, many of whom had underlying diseases. In children, serotype 6B (22\u00b75%) was followed by 19F (14\u00b71%), and 14 (13\u00b71%); potential coverages of PCV7 and PCV13 were 75\u00b74% and 93\u00b77%, respectively. In adults, serotype 12F (14\u00b73%) was followed by 3 (11\u00b73%), and 6B (10\u00b73%); 23-valent polysaccharide vaccine (PPV23) coverage was 85\u00b74%. Most serotype 12F strains were gPISP, with<jats:italic>pbp2b<\/jats:italic>gene alteration; carbapenem had an excellent MIC<jats:sub>90.<\/jats:sub>PCV7 is recommended for children and PPV23 for adults to increase prevention against IPD.<\/jats:p>","DOI":"10.1017\/s0950268809990239","type":"journal-article","created":{"date-parts":[[2009,6,19]],"date-time":"2009-06-19T12:55:20Z","timestamp":1245416120000},"page":"61-68","source":"Crossref","is-referenced-by-count":76,"title":["Serotype and antibiotic resistance of isolates from patients with invasive pneumococcal disease in Japan"],"prefix":"10.1017","volume":"138","author":[{"given":"N.","family":"CHIBA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"MOROZUMI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"SUNAOSHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"TAKAHASHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"TAKANO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"KOMORI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"SUNAKAWA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"UBUKATA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2009,6,19]]},"reference":[{"key":"S0950268809990239_ref022","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.5.1488-1494.2004"},{"key":"S0950268809990239_ref028","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2008.02593.x"},{"key":"S0950268809990239_ref010","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-003-0278-Y"},{"key":"S0950268809990239_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2004.04.004"},{"key":"S0950268809990239_ref017","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.14.1668"},{"key":"S0950268809990239_ref026","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/48.6.915"},{"key":"S0950268809990239_ref015","first-page":"893","article-title":"Direct and indirect effects of routine vaccination of children with 7-valent pneumococcal conjugate vaccine on incidence of invasive pneumococcal disease \u2013 United States, 1998\u20132003","volume":"54","year":"2005","journal-title":"Morbidity Mortality Weekly Report"},{"key":"S0950268809990239_ref020","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000253059.84602.c3"},{"key":"S0950268809990239_ref023","doi-asserted-by":"publisher","DOI":"10.1007\/BF02350645"},{"key":"S0950268809990239_ref030","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-003-0258-2"},{"key":"S0950268809990239_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(67)92346-X"},{"key":"S0950268809990239_ref003","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/15.1.77"},{"key":"S0950268809990239_ref021","first-page":"144","article-title":"Invasive pneumococcal disease in children 5 years after conjugate vaccine introduction \u2013 eight states, 1998\u20132005","volume":"57","year":"2008","journal-title":"Morbidity Mortality Weekly Report"},{"key":"S0950268809990239_ref019","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31803df9ca"},{"key":"S0950268809990239_ref007","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2807\/esm.11.09.00646-en","article-title":"Pneumococcal disease surveillance in Europe","volume":"11","author":"Pebody","year":"2006","journal-title":"Eurosurveillance"},{"key":"S0950268809990239_ref025","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(86)90215-5"},{"key":"S0950268809990239_ref014","first-page":"1","article-title":"Preventing pneumococcal disease among infants and young children. 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