{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:52:46Z","timestamp":1762865566138},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,7,21]],"date-time":"2009-07-21T00:00:00Z","timestamp":1248134400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>To monitor the changing trend of extended-spectrum \u03b2-lactamase (ESBL)-producing bacteria, a 7-year continuous study was launched in 2001 at the largest tertiary hospital in Taiwan. A significant increase over the study period was evident for ESBL-producing isolates of<jats:italic>Escherichia coli<\/jats:italic>(4\u00b78\u201310\u00b70%) and<jats:italic>Klebsiella pneumoniae<\/jats:italic>(15\u00b70\u201323\u00b74%). Molecular investigation conducted in three separate periods revealed the prevalent ESBL types and their genetic relatedness. CTX-M-producing isolates (73\u00b78%) were more prevalent than SHV-type ESBLs (37\u00b70%), the most frequent being CTX-M-14 (34\u00b73%), CTX-M-3 (25\u00b79%), and SHV-12 (25\u00b77%). However, a marked increase of CTX-M-15-producing isolates from 2\u00b71% in 2002 to 29\u00b76% in 2007 was also noted. The increase of ESBL-producing isolates in both species may be mainly due to the horizontal transmission of resistance plasmids, while clonal expansion of some epidemic strains further added to the dispersion of ESBL-producing<jats:italic>K. pneumoniae<\/jats:italic>.<\/jats:p>","DOI":"10.1017\/s0950268809990409","type":"journal-article","created":{"date-parts":[[2009,7,21]],"date-time":"2009-07-21T10:19:41Z","timestamp":1248171581000},"page":"253-263","source":"Crossref","is-referenced-by-count":26,"title":["A 7-year surveillance for ESBL-producing<i>Escherichia coli<\/i>and<i>Klebsiella pneumoniae<\/i>at a university hospital in Taiwan: the increase of CTX-M-15 in the ICU"],"prefix":"10.1017","volume":"138","author":[{"given":"J. C.","family":"SHU","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"CHIA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"KUO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. H.","family":"SU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. L.","family":"WU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,7,21]]},"reference":[{"key":"S0950268809990409_ref024","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00171-08"},{"key":"S0950268809990409_ref022","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl483"},{"key":"S0950268809990409_ref038","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn380"},{"key":"S0950268809990409_ref003","doi-asserted-by":"publisher","DOI":"10.1007\/BF01641355"},{"key":"S0950268809990409_ref026","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh424"},{"key":"S0950268809990409_ref021","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01857.x"},{"key":"S0950268809990409_ref042","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2007.06.007"},{"key":"S0950268809990409_ref015","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.12.5715-5721.2004"},{"key":"S0950268809990409_ref027","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01974-07"},{"key":"S0950268809990409_ref041","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00909-06"},{"key":"S0950268809990409_ref035","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01855.x"},{"key":"S0950268809990409_ref001","doi-asserted-by":"publisher","DOI":"10.1007\/BF01644127"},{"key":"S0950268809990409_ref029","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn182"},{"key":"S0950268809990409_ref012","first-page":"553","volume-title":"Diagnostic Molecular Microbiology: Principle and Applications","author":"Mabilat","year":"1993"},{"key":"S0950268809990409_ref043","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.12.015"},{"key":"S0950268809990409_ref011","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.9.4486-4491.2005"},{"key":"S0950268809990409_ref005","doi-asserted-by":"publisher","DOI":"10.1086\/500662"},{"key":"S0950268809990409_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0196-6553(88)90053-3"},{"key":"S0950268809990409_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2008.03.005"},{"key":"S0950268809990409_ref032","doi-asserted-by":"crossref","DOI":"10.2807\/ese.13.47.19044-en","article-title":"Increasing prevalence of ESBL-producing Enterobacteriaceae in Europe","volume":"13","author":"Coque","year":"2008","journal-title":"Eurosurveillance"},{"key":"S0950268809990409_ref016","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-008-0610-7"},{"key":"S0950268809990409_ref036","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.1.362-364.2004"},{"key":"S0950268809990409_ref020","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2005.08.016"},{"key":"S0950268809990409_ref014","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.6.1985-1988.2002"},{"key":"S0950268809990409_ref031","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.11.013"},{"key":"S0950268809990409_ref028","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00852-08"},{"key":"S0950268809990409_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2005.04.004"},{"key":"S0950268809990409_ref009","unstructured":"9. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing, 15th informational supplement M100-S15. Clinical and Laboratory Standards Institute, Wayne, PA, 2005."},{"key":"S0950268809990409_ref030","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00107-08"},{"key":"S0950268809990409_ref044","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.01.007"},{"key":"S0950268809990409_ref040","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn463"},{"key":"S0950268809990409_ref007","first-page":"264","article-title":"Extended-spectrum \u03b2-lactamases in Taiwan: epidemiology, detection, treatment and infection control","volume":"39","author":"Yu","year":"2006","journal-title":"Journal of Microbiology, Immunology, and Infection"},{"key":"S0950268809990409_ref004","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1086\/319610","article-title":"New \u03b2-lactamases in gram-negative bacteria: diversity and impact on the selection of antimicrobial therapy","volume":"32","author":"Bush","year":"2001","journal-title":"Clinical Infectious Diseases"},{"key":"S0950268809990409_ref017","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl199"},{"key":"S0950268809990409_ref013","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1128\/AAC.41.3.647","article-title":"Evolution of extended-spectrum \u03b2-lactam resistance (SHV-8) in a strain of Escherichia coli during multiple episodes of bacteremia","volume":"41","author":"Rasheed","year":"1997","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"S0950268809990409_ref025","first-page":"237","article-title":"Plasmid-mediated extended-spectrum \u03b2-lactamase (CTX-M-3 like) from India and gene association with insertion sequence ISEcp1","volume":"201","author":"Karim","year":"2001","journal-title":"FEMS Microbiology Letters"},{"key":"S0950268809990409_ref010","doi-asserted-by":"publisher","DOI":"10.1053\/jhin.2000.0815"},{"key":"S0950268809990409_ref033","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00576-07"},{"key":"S0950268809990409_ref037","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01377-06"},{"key":"S0950268809990409_ref034","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01538-07"},{"key":"S0950268809990409_ref023","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01848.x"},{"key":"S0950268809990409_ref006","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2006.12.203"},{"key":"S0950268809990409_ref039","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm464"},{"key":"S0950268809990409_ref018","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki117"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268809990409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T22:15:43Z","timestamp":1633731343000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268809990409\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,21]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S0950268809990409"],"URL":"https:\/\/doi.org\/10.1017\/s0950268809990409","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,21]]}}}