{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:20:53Z","timestamp":1773793253386,"version":"3.50.1"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2009,10,2]],"date-time":"2009-10-02T00:00:00Z","timestamp":1254441600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>A retrospective study of clinical characteristics, outcome and prognostic factors of patients with cryptococcosis was undertaken in intensive care units (ICUs) of a medical centre for the period 2000\u20132005. Twenty-six patients with<jats:italic>Cryptococcus neoformans<\/jats:italic>var.<jats:italic>grubii<\/jats:italic>infection were identified (16 males, median age 58 years). The most frequent underlying diseases were liver cirrhosis (38\u00b75%), diabetes mellitus (26\u00b79%) and HIV infection (19\u00b72%). The most frequently identified sites of infection were blood (61\u00b75%), cerebrospinal fluid (38\u00b75%) and airways (34\u00b76%). The mean Acute Physiologic and Chronic Health Evaluation II score at ICU admission was 22\u00b746. The ICU mortality rate in these patients was 73\u00b71% (19\/26) and there were a further two mortalities recorded after discharge from ICU, reaching a total mortality rate of 80\u00b78% (21\/26). Patients with ICU survival &gt;2 weeks had lower rates of HIV infection (<jats:italic>P<\/jats:italic>=0\u00b7004), less use of inotropic agents during ICU stay (<jats:italic>P<\/jats:italic>&lt;0\u00b7001) and lower white blood cell counts (<jats:italic>P<\/jats:italic>=0\u00b701). After adjusting for clinical variables in the multivariate Cox regression model, diabetes and cryptococcal infection after ICU admission were independent predictors of good long-term prognosis (<jats:italic>P<\/jats:italic>=0\u00b7015) and HIV infectious status was associated with poor outcome (<jats:italic>P<\/jats:italic>=0\u00b7012).<\/jats:p>","DOI":"10.1017\/s0950268809990926","type":"journal-article","created":{"date-parts":[[2009,10,2]],"date-time":"2009-10-02T11:12:55Z","timestamp":1254481975000},"page":"1036-1043","source":"Crossref","is-referenced-by-count":8,"title":["Disseminated<i>Cryptococcus neoformans<\/i>var.<i>grubii<\/i>infections in intensive care units"],"prefix":"10.1017","volume":"138","author":[{"given":"Y.-M.","family":"CHUANG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. C.","family":"KU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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