{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:53:49Z","timestamp":1762458829879},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2010,10,26]],"date-time":"2010-10-26T00:00:00Z","timestamp":1288051200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>In contrast to bacteraemic pneumococcal community-acquired pneumonia (CAP), there is a paucity of data on the clinical characteristics and outcomes of non-bacteraemic pneumococcal CAP. This retrospective study compared the outcome of hospitalized patients with bacteraemic and non-bacteraemic pneumococcal CAP treated at a medical centre from 2004 to 2008. Data on clinical outcomes including all-cause mortality, length of hospital stay, need for intensive-care unit admission and extrapulmonary involvement were analysed. In all, 221 patients with pneumococcal pneumonia (87 bacteraemic, 134 non-bacteraemic) were included. Patients with bacteraemic pneumococcal pneumonia (BPP) were older than those with non-BPP (46\u00b72\u00b130\u00b77 years <jats:italic>vs<\/jats:italic>. 21\u00b77\u00b130\u00b78 years, <jats:italic>P<\/jats:italic>&lt;0\u00b7001) and were more likely to have underlying medical diseases (66\u00b77% <jats:italic>vs<\/jats:italic>. 33\u00b76%, <jats:italic>P<\/jats:italic>&lt;0\u00b7001). The overall mortality rates at 7, 14, and 30 days were significantly higher in BPP than non-BPP patients (12\u00b76% <jats:italic>vs<\/jats:italic>. 2\u00b72%, 14\u00b79% <jats:italic>vs<\/jats:italic>. 3\u00b77%, 19\u00b75% <jats:italic>vs<\/jats:italic>. 5\u00b71%, all <jats:italic>P<\/jats:italic>&lt;0\u00b701). Multivariate logistic regression analysis showed that pneumococcal bacteraemia was correlated with extrapulmonary involvement (odds ratio 5\u00b746, 95% confidence interval 1\u00b797\u201315\u00b716, <jats:italic>P<\/jats:italic>=0\u00b7001). In conclusion, <jats:italic>S. pneumoniae<\/jats:italic> bacteraemia increased the risk of mortality and extrapulmonary involvement in patients with pneumococcal CAP.<\/jats:p>","DOI":"10.1017\/s0950268810002402","type":"journal-article","created":{"date-parts":[[2010,10,26]],"date-time":"2010-10-26T10:37:06Z","timestamp":1288089426000},"page":"1307-1316","source":"Crossref","is-referenced-by-count":30,"title":["Outcomes of hospitalized patients with bacteraemic and non-bacteraemic community-acquired pneumonia caused by <i>Streptococcus pneumoniae<\/i>"],"prefix":"10.1017","volume":"139","author":[{"given":"S.-H.","family":"LIN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.-C.","family":"LAI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.-K.","family":"TAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.-H.","family":"LIAO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.-R.","family":"HSUEH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2010,10,26]]},"reference":[{"key":"S0950268810002402_ref012","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-1800"},{"key":"S0950268810002402_ref024","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.6.848"},{"key":"S0950268810002402_ref034","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2009.02658.x"},{"key":"S0950268810002402_ref018","unstructured":"18. 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