{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:03:59Z","timestamp":1791266639865,"version":"4.1.0"},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2010,11,19]],"date-time":"2010-11-19T00:00:00Z","timestamp":1290124800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Data about the effectiveness of different antibiotic regimens for the treatment of acute Q fever from clinical studies is scarce. We analysed the antibiotic treatment regimens of acute Q fever patients in 2007 and 2008 in The Netherlands and assessed whether hospitalization after a minimum of 2 days antibiotic therapy was related to the initial antibiotic therapy. Clinical data on antibiotic treatment and risk factors of acute Q fever patients were obtained from general practitioner medical records and self-reported by patients. For the 438 study patients, doxycycline was the most commonly prescribed initial antibiotic in both study years. After adjustments for confounding factors, doxycycline (200 mg\/day), moxifloxacin, as well as other possibly effective antibiotics [including other new fluoroquinolones and doxycycline (100 mg\/day)] showed significant lower risks for hospitalization compared to \u03b2-lactam antibiotics and azithromycin (reference group), with the lowest risk for doxycycline (200 mg\/day) (odds ratio 0\u00b704, 95% confidence interval 0\u00b701\u20130\u00b722). These data support current guidelines that recommend doxycycline as the first choice antibiotic for treating acute Q fever.<\/jats:p>","DOI":"10.1017\/s0950268810002621","type":"journal-article","created":{"date-parts":[[2010,11,19]],"date-time":"2010-11-19T06:25:11Z","timestamp":1290147911000},"page":"1332-1341","source":"Crossref","is-referenced-by-count":30,"title":["Antibiotic therapy for acute Q fever in The Netherlands in 2007 and 2008 and its relation to hospitalization"],"prefix":"10.1017","volume":"139","author":[{"given":"F.","family":"DIJKSTRA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"RIPHAGEN-DALHUISEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"WIJERS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"HAK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A. B.","family":"VAN DER SANDE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"MORROY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. M.","family":"SCHNEEBERGER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"SCHIMMER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. W.","family":"NOTERMANS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"VAN DER HOEK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2010,11,19]]},"reference":[{"key":"S0950268810002621_ref009","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.11.3276-3278.2001"},{"key":"S0950268810002621_ref008","doi-asserted-by":"publisher","DOI":"10.1080\/00365540510037858"},{"key":"S0950268810002621_ref011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2004.tb03476.x"},{"key":"S0950268810002621_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2004.05.001"},{"key":"S0950268810002621_ref015","doi-asserted-by":"publisher","DOI":"10.1136\/thx.47.4.276"},{"key":"S0950268810002621_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(05)70052-9"},{"key":"S0950268810002621_ref006","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.12.3644-3646.2001"},{"key":"S0950268810002621_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68266-4"},{"key":"S0950268810002621_ref003","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1128\/CMR.12.4.518","article-title":"Q fever","volume":"12","author":"Maurin","year":"1999","journal-title":"Clinical Microbiology Reviews"},{"key":"S0950268810002621_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2003.07.007"},{"key":"S0950268810002621_ref010","doi-asserted-by":"crossref","first-page":"947","DOI":"10.4269\/ajtmh.2005.73.947","article-title":"Q Fever pneumonia: are clarithromycin and moxifloxacin alternative treatments only?","volume":"73","author":"Morovic","year":"2005","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"S0950268810002621_ref007","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.1.301-302.2001"},{"key":"S0950268810002621_ref012","doi-asserted-by":"publisher","DOI":"10.1086\/520661"},{"key":"S0950268810002621_ref004","first-page":"662","article-title":"Q fever in the Netherlands: 2008 and expectations for 2009 [in Dutch]","volume":"153","author":"van Steenbergen","year":"2009","journal-title":"Nederlands Tijdschrift voor Geneeskunde"},{"key":"S0950268810002621_ref016","first-page":"1998","article-title":"An outbreak of Q fever in The Netherlands \u2013 possible link to goats [in Dutch]","volume":"151","author":"Van Steenbergen","year":"2007","journal-title":"Nederlands Tijdschrift voor Geneeskunde"},{"key":"S0950268810002621_ref005","first-page":"20","article-title":"Diagnosis and treatment of Q fever [in Dutch]","volume":"16","author":"Nabuurs-Franssen","year":"2008","journal-title":"Nederlands Tijdschrift voor Medische Microbiologie"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268810002621","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T02:28:44Z","timestamp":1556332124000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268810002621\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,19]]},"references-count":16,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0950268810002621"],"URL":"https:\/\/doi.org\/10.1017\/s0950268810002621","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,19]]}}}