{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:58:02Z","timestamp":1791122282825,"version":"4.1.0"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2010,12,7]],"date-time":"2010-12-07T00:00:00Z","timestamp":1291680000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Overuse of antimicrobials in food-animal production is thought to be a major risk factor for the development of resistant bacterial populations. Data on non-human antimicrobial usage is essential for planning of intervention strategies to lower resistance levels at the country, region or herd levels. In this study we evaluated Danish national antimicrobial usage data for five antimicrobial classes used in slaughter pigs in different herd sizes and data on the number of slaughter pigs produced per herd, between 2002 and 2008, in Denmark. The objective was to ascertain if there is an association between herd size and amount of antimicrobials consumed. During this period, the overall number of herds with slaughter pigs decreased by 43%, with larger herds becoming more prevalent. The tetracycline treatment incidence (TI) rate increased from 0\u00b728 to 0\u00b770 animal-defined daily dose (ADD)\/100 slaughter pig-days at risk while macrolide TI presented a more moderate increase, from 0\u00b740 to 0\u00b744 ADD\/100 slaughter pig-days at risk during the study period. Linear regression analyses revealed a significant association between herd size and TI rates for tetracyclines, macrolides, sulfonamides\/trimethoprim and cephalosporins, with small herds presenting significantly higher TI than moderate, large and the largest herds. This study highlights the importance of establishing an antimicrobial consumption monitoring programme, integrated with comprehensive food-animal production surveillance. Further research should be performed to address the potential causes of the detected associations between herd sizes and antimicrobial consumption in pigs.<\/jats:p>","DOI":"10.1017\/s0950268810002724","type":"journal-article","created":{"date-parts":[[2010,12,7]],"date-time":"2010-12-07T11:02:34Z","timestamp":1291719754000},"page":"1601-1609","source":"Crossref","is-referenced-by-count":24,"title":["Trends in slaughter pig production and antimicrobial consumption in Danish slaughter pig herds, 2002\u20132008"],"prefix":"10.1017","volume":"139","author":[{"given":"A. R.","family":"VIEIRA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M.","family":"PIRES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"HOUE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.-D.","family":"EMBORG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2010,12,7]]},"reference":[{"key":"S0950268810002724_ref012","unstructured":"12. WHO. Critically important antimicrobials for human medicine: categorization for the development of risk management strategies to contain antimicrobial resistance due to non-human antimicrobial use: report of the second WHO Expert Meeting, Copenhagen, 29\u201331 May 2007."},{"key":"S0950268810002724_ref006","unstructured":"6. Statistics Denmark. (http:\/\/www.statistikbanken.dk\/BRUG6). Accessed 22 September 2010."},{"key":"S0950268810002724_ref010","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2885.2001.00315.x"},{"key":"S0950268810002724_ref004","doi-asserted-by":"publisher","DOI":"10.20506\/rst.20.3.1317"},{"key":"S0950268810002724_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2005.10.003"},{"key":"S0950268810002724_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5877(02)00091-0"},{"key":"S0950268810002724_ref003","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7159.609"},{"key":"S0950268810002724_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2004.04.001"},{"key":"S0950268810002724_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5877(02)00233-7"},{"key":"S0950268810002724_ref018","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.prevetmed.2007.07.009","article-title":"A survey on biosecurity and management practices in Belgian pig herds","volume":"83","author":"De Sadeleer","year":"2008","journal-title":"Preventive Veterinary Medicine"},{"key":"S0950268810002724_ref016","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1128\/9781555817534.ch22","volume-title":"Antimicrobial Resistance in Bacteria of Animal Origin","author":"Grave","year":"2006"},{"key":"S0950268810002724_ref013","first-page":"87","article-title":"Antimicrobial drug use and related management practices among Ontario swine producers","volume":"39","author":"Dunlop","year":"1998","journal-title":"Canadian Veterinary Journal"},{"key":"S0950268810002724_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5877(96)01082-3"},{"key":"S0950268810002724_ref011","unstructured":"11. Danish Veterinary and Food Administration. Concept for treatment guidelines for production animals (http:\/\/www.foedevarestyrelsen.dk\/NR\/rdonlyres\/C2FDF204-0819-438A-86CF-8A4B90325015\/0\/Behandlingsvejledningantibiotikasvinskema.pdf). Accessed 22 September 2010."},{"key":"S0950268810002724_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5877(97)00093-7"},{"key":"S0950268810002724_ref002","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2005.pto960401.x"},{"key":"S0950268810002724_ref005","unstructured":"5. Anon. DANMAP 2008 \u2013 use of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from food animals, foods and humans in Denmark, 2008."},{"key":"S0950268810002724_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(00)00145-X"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268810002724","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,14]],"date-time":"2020-06-14T11:24:50Z","timestamp":1592133890000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268810002724\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,7]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0950268810002724"],"URL":"https:\/\/doi.org\/10.1017\/s0950268810002724","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,7]]}}}