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In this study 249 <jats:italic>Cryptosporidium parvum<\/jats:italic> isolates collected from Irish patients between 2000 and 2009 were subtyped by sequence analysis of the GP60 locus. A subsample of 127 isolates was also typed at the MS1 and ML1 loci. GP60 subtype IIaA18G3R1 was the predominant subtype in every year and every season throughout the country. Over the 10-year period there was no evidence that host immunity to the predominant subtype caused a shift in its prevalence. Length frequency distributions of the GP60 TCA\/TCG repeats compiled from published data, showed distinct patterns for countries with predominantly zoonotic or anthroponotic transmission cycles, respectively. Although considered to be mostly affected by zoonotic cryptosporidiosis, the GP60 fragment length of Irish <jats:italic>C. parvum<\/jats:italic> isolates mirrored that of countries with predominantly human-to-human transmission, indicating more complex routes of infection between livestock and humans. Due to their homogeneity, ML1 and MS1 were not considered useful loci for subtyping <jats:italic>C. parvum<\/jats:italic> strains in Ireland.<\/jats:p>","DOI":"10.1017\/s0950268810002992","type":"journal-article","created":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T11:02:59Z","timestamp":1296558179000},"page":"1945-1955","source":"Crossref","is-referenced-by-count":17,"title":["Longitudinal and spatial distribution of GP60 subtypes in human cryptosporidiosis cases in Ireland"],"prefix":"10.1017","volume":"139","author":[{"given":"A.","family":"ZINTL","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"EZZATY-MIRASHEMI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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