{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:29:14Z","timestamp":1761128954566},"reference-count":36,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2011,8,30]],"date-time":"2011-08-30T00:00:00Z","timestamp":1314662400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>An outbreak of meningococcal disease (MD) with severe morbidity and mortality was investigated in midwestern Brazil in order to identify control measures. A MD case was defined as isolation of<jats:italic>Neisseria meningitidis<\/jats:italic>, or detection of polysaccharide antigen in a sterile site, or presence of clinical purpura fulminans, or an epidemiological link with a laboratory-confirmed case-patient, between June and August 2008. In 8 out of 16 MD cases studied, serogroup C ST103 complex was identified. Five (31%) cases had neurological findings and five (31%) died. The attack rate was 12 cases\/100 000 town residents and 60 cases\/100 000 employees in a large local food-processing plant. We conducted a matched case-control study of eight primary laboratory-confirmed cases (1:4). Factors associated with illness in single variable analysis were work at the processing plant [matched odds ratio (mOR) 22, 95% confidence interval (CI) 2\u00b73\u2013207\u00b77,<jats:italic>P<\/jats:italic>&lt;0\u00b701], and residing &lt;1 year in Rio Verde (mOR 7, 95% CI 1\u00b711\u201343\u00b79,<jats:italic>P<\/jats:italic>&lt;0\u00b702). Mass vaccination (&gt;10 000 plant employees) stopped propagation in the plant, but not in the larger community.<\/jats:p>","DOI":"10.1017\/s0950268811001610","type":"journal-article","created":{"date-parts":[[2011,8,30]],"date-time":"2011-08-30T10:33:40Z","timestamp":1314700420000},"page":"906-915","source":"Crossref","is-referenced-by-count":21,"title":["Outbreak of<i>Neisseria meningitidis<\/i>C in workers at a large food-processing plant in Brazil: challenges of controlling disease spread to the larger community"],"prefix":"10.1017","volume":"140","author":[{"given":"B. P. M.","family":"ISER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. C. A. V.","family":"LIMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"De MORAES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. P. A.","family":"De ALMEIDA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. T.","family":"WATANABE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. L. A.","family":"ALVES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. P. S.","family":"LEMOS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C. O.","family":"GORLA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. G.","family":"GON\u00c7ALVES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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Wayne, PA: Clinical and Laboratory Standards Institute, 2008."},{"key":"S0950268811001610_ref022","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2006.00050.x"},{"key":"S0950268811001610_ref015","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.1.320-328.2004"},{"key":"S0950268811001610_ref007","doi-asserted-by":"publisher","DOI":"10.1086\/597257"},{"key":"S0950268811001610_ref012","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520290035026"},{"key":"S0950268811001610_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61016-2"},{"key":"S0950268811001610_ref030","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.6.472"},{"key":"S0950268811001610_ref023","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.1.75-85.2001"},{"key":"S0950268811001610_ref029","first-page":"13","article-title":"Control and prevention of serogroup C meningococcal disease: evaluation and management of suspected outbreaks: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"46","year":"1997","journal-title":"Morbidity and Mortality Weekly Report. Recommendations and Reports"},{"key":"S0950268811001610_ref002","first-page":"264","article-title":"Meningococcal meningitis outbreak control strategies","volume":"32","author":"Ahlawat","year":"2000","journal-title":"Journal of Communicable Diseases"},{"key":"S0950268811001610_ref024","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1128\/JCM.33.9.2233-2239.1995","article-title":"Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing","volume":"33","author":"Tenover","year":"1995","journal-title":"Journal of Clinical Microbiology"},{"key":"S0950268811001610_ref020","unstructured":"20. CLSI. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Supplement M7-A7. Clinical and Laboratory Standards Institute, Wayne, PA, 2006."},{"key":"S0950268811001610_ref028","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(93)90236-Q"},{"key":"S0950268811001610_ref032","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.6.435"},{"key":"S0950268811001610_ref017","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.4.1553-1558.2001"},{"key":"S0950268811001610_ref003","unstructured":"3. Sistema de Alerta e Resposta Apropriada (SARA). Meningites: normas de procedimento, 2a edi\u00e7\u00e3o. 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