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Documentation of the peculiar, fatal predisposition of pregnant women during outbreaks of jaundice identifies hepatitis E and enables construction of its epidemic history. Between the last decade of the 18th century and the early decades of the 20th century, hepatitis E-like outbreaks were reported mainly from Western Europe and several of its colonies. During the latter half of the 20th century, reports of these epidemics, including those that became serologically confirmed as hepatitis E, emanated from, first, the eastern and southern Mediterranean littoral and, thereafter, Southern and Central Asia, Eastern Europe, and the rest of Africa. The dispersal has been accompanied by a trend towards more frequent and larger-scale occurrences. Epidemic and endemic hepatitis E still beset people inhabiting Asia and Africa, especially pregnant women and their fetuses and infants. Their relief necessitates not only accelerated access to potable water and sanitation but also vaccination against hepatitis E.<\/jats:p>","DOI":"10.1017\/s0950268811002925","type":"journal-article","created":{"date-parts":[[2012,1,25]],"date-time":"2012-01-25T11:54:30Z","timestamp":1327492470000},"page":"767-787","source":"Crossref","is-referenced-by-count":76,"title":["Fatal outbreaks of jaundice in pregnancy and the epidemic history of hepatitis E"],"prefix":"10.1017","volume":"140","author":[{"given":"C.-G.","family":"TEO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2012,1,25]]},"reference":[{"key":"S0950268811002925_ref308","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61403-1"},{"key":"S0950268811002925_ref293","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-7-336"},{"key":"S0950268811002925_ref296","doi-asserted-by":"publisher","DOI":"10.1080\/00365540310010930"},{"key":"S0950268811002925_ref281","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(89)90731-1"},{"key":"S0950268811002925_ref197","first-page":"35","article-title":"Pattern of jaundice in pregnancy","volume":"29","author":"Zuberi","year":"1979","journal-title":"Journal of the Pakistan Medical Association"},{"key":"S0950268811002925_ref277","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1994.51.466"},{"key":"S0950268811002925_ref194","first-page":"11","article-title":"The aetiological pattern of jaundice in Gujarat","volume":"55","author":"Shah","year":"1970","journal-title":"Journal of the Indian Medical Association"},{"key":"S0950268811002925_ref159","first-page":"145","article-title":"An epidemic of infectious hepatitis in the Kathmandu Valley","volume":"11","author":"Hillis","year":"1973","journal-title":"Journal of the Nepal Medical Association"},{"key":"S0950268811002925_ref242","first-page":"257","article-title":"An epidemiologic survey on a type E hepatitis (HE) outbreak [in Chinese]","volume":"12","author":"Xia","year":"1991","journal-title":"Chinese Journal of Epidemiology"},{"key":"S0950268811002925_ref136","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(69)90120-5"},{"key":"S0950268811002925_ref216","first-page":"37","article-title":"Viral hepatitis during pregnancy. 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