{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T23:36:39Z","timestamp":1771889799573,"version":"3.50.1"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2012,2,20]],"date-time":"2012-02-20T00:00:00Z","timestamp":1329696000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>We investigated the positive predictive value (PPV) of a solitary positive immunoglobulin M (IgM) phase II response for the serodiagnosis of acute Q fever detected with either an indirect immunofluorescence assay (IFA) or an enzyme-linked immunosorbent assay (ELISA). Initial and follow-up sera from patients suspected of acute Q fever were included if initially only IgM phase II tested positive with IFA in 2008 (<jats:italic>n<\/jats:italic>=92), or ELISA in 2009 (<jats:italic>n<\/jats:italic>=85). A seroconversion for Q fever was defined as an initial sample being IgG phase II negative but positive in the follow-up sample. The PPV of an initial isolated IgM phase II result detected by IFA or ELISA was 65% and 51%, respectively, and therefore appeared not to adequately predict acute Q fever. For this reason it cannot be used as a diagnostic criterion nor should it be included in public health notification without confirmation with other markers or a follow-up serum sample.<\/jats:p>","DOI":"10.1017\/s0950268812000118","type":"journal-article","created":{"date-parts":[[2012,2,20]],"date-time":"2012-02-20T09:52:19Z","timestamp":1329731539000},"page":"1950-1954","source":"Crossref","is-referenced-by-count":11,"title":["Solitary IgM phase II response has a limited predictive value in the diagnosis of acute Q fever"],"prefix":"10.1017","volume":"140","author":[{"given":"C. F. H.","family":"RAVEN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L. A.","family":"HAUTVAST","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"HERREMANS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. C. A. P.","family":"LEENDERS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. M.","family":"SCHNEEBERGER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2012,2,20]]},"reference":[{"key":"S0950268812000118_ref008","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1128\/JCM.38.4.1645-1647.2000","article-title":"Comparison of a commercial enzyme-linked immunosorbent assay with immunofluorescence and complement fixation tests for detection of Coxiella burnetii (Q fever) immunoglobulin M","volume":"38","author":"Field","year":"2000","journal-title":"Journal of Clinical Microbiology"},{"key":"S0950268812000118_ref016","unstructured":"16. RIVM. National Institute for Public Health and the Environment (RIVM), The Netherlands (http:\/\/www.rivm.nl\/Bibliotheek\/Professioneel_Praktisch\/Richtlijnen\/LCI_richtlijnen\/Q_koorts). Accessed 6 May 2011."},{"key":"S0950268812000118_ref012","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1374.112"},{"key":"S0950268812000118_ref015","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1128\/JCM.22.4.484-487.1985","article-title":"Immunoglobulin responses in acute Q fever","volume":"22","author":"Dupuis","year":"1985","journal-title":"Journal of Clinical Microbiology"},{"key":"S0950268812000118_ref003","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268810002268"},{"key":"S0950268812000118_ref004","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02293-10"},{"key":"S0950268812000118_ref007","doi-asserted-by":"publisher","DOI":"10.1007\/BF01691965"},{"key":"S0950268812000118_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2009.06.004"},{"key":"S0950268812000118_ref017","unstructured":"17. Centers for Disease Control and Prevention (http:\/\/www.cdc.gov\/osels\/ph_surveillance\/nndss\/casedef\/q_fever_2009.htm). Accessed 6 May 2011."},{"key":"S0950268812000118_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(05)70052-9"},{"key":"S0950268812000118_ref001","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1128\/CMR.12.4.518","article-title":"Q fever","volume":"12","author":"Maurin","year":"1999","journal-title":"Clinical Microbiology Reviews"},{"key":"S0950268812000118_ref013","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.11.5094-5098.2003"},{"key":"S0950268812000118_ref011","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1128\/CDLI.1.2.189-196.1994","article-title":"Q fever serology: cutoff determination for microimmunofluorescence","volume":"1","author":"Dupont","year":"1994","journal-title":"Clinical and Diagnostic Laboratory Immunology"},{"key":"S0950268812000118_ref009","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00009-11"},{"key":"S0950268812000118_ref006","first-page":"A2388","article-title":"Laboratory diagnosis of acute Q fever [in Dutch]","volume":"154","author":"Wegdam-Blans","year":"2010","journal-title":"Nederlands Tijdschrift voor Geneeskunde"},{"key":"S0950268812000118_ref018","unstructured":"18. Forland F , ECDC Technical report Risk assessment on Q fever, 2010. Report No.: 10.2900\/28860."},{"key":"S0950268812000118_ref005","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00454-09"},{"key":"S0950268812000118_ref014","first-page":"A1845","article-title":"Three years of Q fever in the Netherlands: faster diagnosis [in Dutch]","volume":"154","author":"Hoek","year":"2010","journal-title":"Nederlands Tijdschrift voor Geneeskunde"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268812000118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T18:37:14Z","timestamp":1593715034000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268812000118\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,20]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0950268812000118"],"URL":"https:\/\/doi.org\/10.1017\/s0950268812000118","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,20]]}}}