{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:24:59Z","timestamp":1790029499258,"version":"4.0.1"},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2012,6,7]],"date-time":"2012-06-07T00:00:00Z","timestamp":1339027200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/2.5\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The Belgian data (2003\u20132010) for the European Antimicrobial Resistance Surveillance Network (EARS-Net) showed a significant decreasing trend in the proportion of penicillin non-susceptible<jats:italic>Streptococcus pneumoniae<\/jats:italic>(9\u00b74% to &lt;1%) from blood and CSF isolates. We found that 75% of this decrease was explained by a change in Clinical and Laboratory Standards Institute (CLSI) breakpoints as the trend disappeared if only the new breakpoints were applied. Applying only European Committee on Antimicrobial Susceptibility Testing (EUCAST) breakpoints also resulted in a relatively stable proportion of penicillin non-susceptibility (average 5%), but this proportion was 7\u201313 times higher than with the new CLSI breakpoints. When the new CLSI breakpoints alone are used, fewer than 1% of bacteraemia isolates were penicillin non-susceptible during the entire period, but the proportion of non-susceptible meningitis isolates rose from 6\u00b73% in 2003 to 15\u00b79% between 2003 and 2010. Changing breakpoints should lead to retrospective analysis of historical data to minimize wrongly interpreting resistance trends.<\/jats:p>","DOI":"10.1017\/s0950268812001057","type":"journal-article","created":{"date-parts":[[2012,6,7]],"date-time":"2012-06-07T14:01:43Z","timestamp":1339077703000},"page":"490-495","source":"Crossref","is-referenced-by-count":15,"title":["Antimicrobial resistance to benzylpenicillin in invasive pneumococcal disease in Belgium, 2003\u20132010: the effect of altering clinical breakpoints"],"prefix":"10.1017","volume":"141","author":[{"given":"M. C.","family":"GOOSSENS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"CATRY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"VERHAEGEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2012,6,7]]},"reference":[{"key":"S0950268812001057_ref2","unstructured":"European Centre for Disease Prevention and Control. Antimicrobial resistance surveillance in Europe 2010. Annual report of the European Antimicrobial Resistance Surveillance Network (EARS-Net). Stockholm: ECDC, 2011."},{"key":"S0950268812001057_ref4","unstructured":"Clinical Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; 15th informational supplement M100-S15. Wayne, PA: CLSI, 2005."},{"key":"S0950268812001057_ref3","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1128\/JCM.31.5.1246-1250.1993","article-title":"Testing of Streptococcus pneumoniae for resistance to penicillin","volume":"31","author":"Marshall","year":"1993","journal-title":"Journal of Clinical Microbiology"},{"key":"S0950268812001057_ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00038-010-0167-y"},{"key":"S0950268812001057_ref6","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268810002773"},{"key":"S0950268812001057_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2008.01.021"},{"key":"S0950268812001057_ref8","first-page":"1353","article-title":"Effects of new penicillin susceptibility breakpoints for Streptococcus pneumoniae","volume":"57","year":"2008","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"S0950268812001057_ref9","doi-asserted-by":"publisher","DOI":"10.1086\/598975"},{"key":"S0950268812001057_ref10","first-page":"55","volume-title":"Antibiotic Resistance: Understanding and Responding to an Emerging Crisis","author":"Drlica","year":"2011"},{"key":"S0950268812001057_ref1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg116"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268812001057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T15:18:00Z","timestamp":1594221480000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268812001057\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,7]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S0950268812001057"],"URL":"https:\/\/doi.org\/10.1017\/s0950268812001057","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,7]]}}}