{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T11:00:45Z","timestamp":1773486045521,"version":"3.50.1"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:00:00Z","timestamp":1339459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Since the implementation of <jats:italic>Streptococcus pneumoniae<\/jats:italic> (SPn) conjugate vaccination (PCV), non-vaccine types have prevailed in invasive pneumococcal disease (IPD), and an increase in <jats:italic>Staphylococcus aureus<\/jats:italic> (SA) burden has been suggested. Here, we assess the epidemiology of SA and SPn nasal carriage in 620 children at day-care centres; 141 of these children had received 1\u20134 PCV7 doses. A higher vaccine dosage was associated with non-vaccine-type SPn carriage. Of all SPn isolates, 45% were PCV7 types, 1% were additional PCV10 types and 22% were the three additional PCV13 types. SA carriage was inversely associated with vaccine-type SPn carriage. SPn serotype 19A showed higher SA co-carriage rates compared to other SPn serotypes. PCV7 implementation does not prevent children from being part of the IPD-related SPn transmission chain. These results contribute to the monitoring of SA- and SPn-related disease and add to the debate on the current national vaccination policy that recently included a change from PCV7 to PCV10.<\/jats:p>","DOI":"10.1017\/s095026881200115x","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T23:00:41Z","timestamp":1339542041000},"page":"631-638","source":"Crossref","is-referenced-by-count":13,"title":["Nasal carriage of <i>Streptococcus pneumoniae<\/i> serotypes and <i>Staphylococcus aureus<\/i> in <i>Streptococcus pneumoniae<\/i>-vaccinated and non-vaccinated young children"],"prefix":"10.1017","volume":"141","author":[{"given":"N. H. T. M.","family":"DUKERS-MUIJRERS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"STOBBERINGH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"BEISSER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. C. H.","family":"BOESTEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"JACOBS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J. P. 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