{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:04:03Z","timestamp":1759935843234},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T00:00:00Z","timestamp":1342137600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>This study compared the fatty-acid profiles of<jats:italic>Brucella canis<\/jats:italic>blood culture isolates obtained from infected dogs in the UK, Germany, Japan, South Africa, Peru, Mexico, Colombia, and Argentina, and from a human clinical case in Argentina, to a bank of isolates obtained from canine outbreaks in the USA. Analysis of a total of 42<jats:italic>B. canis<\/jats:italic>isolates and one reference strain found a marked variation within the species. Fatty-acid analysis showed that only the isolates from Argentina, Colombia, and Mexico, which included the human<jats:italic>B. canis<\/jats:italic>isolate, contained a specific fatty acid, 19:0 cyclopropane (lactobacillic acid), w8c (<jats:italic>cis<\/jats:italic>-11,12-methylene octadecanoic acid), and that this fatty acid, when present, made up a large percentage of overall fatty-acid content. Prior to this study, the cellular fatty-acid 19:0 cyclopropane had been identified in all of the species of<jats:italic>Brucella<\/jats:italic>considered to be pathogenic to humans (<jats:italic>B<\/jats:italic>.<jats:italic>abortus<\/jats:italic>,<jats:italic>B<\/jats:italic>.<jats:italic>melitensis<\/jats:italic>,<jats:italic>B<\/jats:italic>.<jats:italic>suis<\/jats:italic>) except for<jats:italic>B<\/jats:italic>.<jats:italic>canis<\/jats:italic>. Discovering that this fatty acid not only occurs in<jats:italic>B. canis<\/jats:italic>, but also that it is only present in some strains of the species provides a new focus for investigations aimed at identifying the cause of reported geographical variability in human<jats:italic>B. canis<\/jats:italic>infection, and at finding predictors of biological behaviour and human pathogenicity within this<jats:italic>Brucella<\/jats:italic>species.<\/jats:p>","DOI":"10.1017\/s0950268812001240","type":"journal-article","created":{"date-parts":[[2012,11,22]],"date-time":"2012-11-22T14:35:40Z","timestamp":1353594940000},"page":"852-858","source":"Crossref","is-referenced-by-count":3,"title":["Newly identified variability in<i>Brucella canis<\/i>fatty-acid content is associated with geographical origin"],"prefix":"10.1017","volume":"141","author":[{"given":"A.","family":"BROWER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"LUCERO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"OKWUMABUA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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