{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:02:44Z","timestamp":1791295364139,"version":"4.1.0"},"reference-count":32,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2012,8,21]],"date-time":"2012-08-21T00:00:00Z","timestamp":1345507200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p><jats:italic>Shigella<\/jats:italic>is an important bacterial cause of infectious diarrhoea globally. The<jats:italic>Shigella<\/jats:italic>human challenge model has been used since 1946 for a variety of objectives including understanding disease pathogenesis, human immune responses and allowing for an early assessment of vaccine efficacy. A systematic review of the literature regarding experimental shigellosis in human subjects was conducted. Summative estimates were calculated by strain and dose. While a total of 19 studies evaluating nine strains at doses ranging from 10 to 1\u00a0\u00d7\u00a010<jats:sup>10<\/jats:sup>colony-forming units were identified, most studies utilized the<jats:italic>S. sonnei<\/jats:italic>strain 53G and the<jats:italic>S. flexneri<\/jats:italic>strain 2457T. Inoculum solution and pre-inoculation buffering has varied over time although diarrhoea attack rates do not appear to increase above 75\u201380%, and dysentery rates remain fairly constant, highlighting the need for additional dose-ranging studies. Expansion of the model to include additional strains from different serotypes will elucidate serotype and strain-specific outcome variability.<\/jats:p>","DOI":"10.1017\/s0950268812001677","type":"journal-article","created":{"date-parts":[[2012,8,21]],"date-time":"2012-08-21T12:16:22Z","timestamp":1345551382000},"page":"223-232","source":"Crossref","is-referenced-by-count":45,"title":["The<i>Shigella<\/i>human challenge model"],"prefix":"10.1017","volume":"141","author":[{"given":"C. K.","family":"PORTER","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"THURA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. T.","family":"RANALLO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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