{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T07:15:26Z","timestamp":1769238926268,"version":"3.49.0"},"reference-count":40,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T00:00:00Z","timestamp":1348444800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>We undertook a national paediatric seroprevalence survey of measles, mumps and rubella (MMR) in Singapore to assess the impact of the national childhood immunization programme against these three diseases after introduction of the trivalent MMR vaccine in 1990. The survey involved 1200 residual sera of Singapore residents aged 1\u201317 years collected from two hospitals between 2008 and 2010. The overall prevalence of antibodies against measles, mumps and rubella was 83\u00b71% [95% confidence interval (CI) 80\u00b79\u201385\u00b71], 71\u00b78% (95% CI 69\u00b71\u201374\u00b72) and 88\u00b75% (95% CI 86\u00b76\u201390\u00b72), respectively. For all three diseases, the lowest prevalence was in children aged 1 year (47\u00b78\u201362\u00b73%). The seroprevalence of the vaccinated children declined over time. The national MMR immunization programme is effective in raising the herd immunity of the childhood population, although certain age groups are more susceptible to infection, in particular, those who are not eligible for vaccination at age &lt;15 months.<\/jats:p>","DOI":"10.1017\/s0950268812002130","type":"journal-article","created":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T09:30:03Z","timestamp":1348479003000},"page":"1721-1730","source":"Crossref","is-referenced-by-count":14,"title":["Prevalence of antibodies against measles, mumps and rubella in the childhood population in Singapore, 2008\u20132010"],"prefix":"10.1017","volume":"141","author":[{"given":"L. W.","family":"ANG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. Y.","family":"LAI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. H.","family":"TEY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"CUTTER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"JAMES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. T.","family":"GOH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2012,9,24]]},"reference":[{"key":"S0950268812002130_ref19","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1128\/CDLI.11.5.913-918.2004","article-title":"Differential immune responses to primary measles-mumps-rubella vaccination in Israeli children","volume":"11","author":"Rager-Zisman","year":"2004","journal-title":"Clinical and Diagnostic Laboratory Immunology"},{"key":"S0950268812002130_ref8","first-page":"25","article-title":"Seroepidemiology of measles, mumps and rubella in Singapore","volume":"17","year":"1991","journal-title":"Epidemiological News Bulletin"},{"key":"S0950268812002130_ref6","doi-asserted-by":"crossref","first-page":"532","DOI":"10.47102\/annals-acadmedsg.V39N7p532","article-title":"Evaluation on the effectiveness of the national childhood immunization programme in Singapore, 1982\u20132007","volume":"39","author":"Liew","year":"2010","journal-title":"Annals Academy of Medicine Singapore"},{"key":"S0950268812002130_ref5","first-page":"1","article-title":"Progress in the elimination of measles from Singapore","volume":"29","year":"2003","journal-title":"Epidemiological News Bulletin"},{"key":"S0950268812002130_ref12","volume-title":"National Health Survey 2004","year":"2005"},{"key":"S0950268812002130_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(98)00362-4"},{"key":"S0950268812002130_ref4","first-page":"66","article-title":"Introduction of measles-mumps-rubella (MMR) vaccine into the national childhood immunization programme","volume":"15","year":"1989","journal-title":"Epidemiological News Bulletin"},{"key":"S0950268812002130_ref7","first-page":"119","volume-title":"Communicable Diseases Surveillance in Singapore 2010","year":"2011"},{"key":"S0950268812002130_ref3","first-page":"404","article-title":"Rubella in male Singapore adolescents: incidence and effects of vaccination","volume":"25","author":"Ahmad","year":"1984","journal-title":"Singapore Medical Journal"},{"key":"S0950268812002130_ref27","first-page":"1312","article-title":"Resurgence of mumps in Singapore associated with Rubini vaccine","volume":"3","author":"Akehurst","year":"1999","journal-title":"Eurosurveillance"},{"key":"S0950268812002130_ref18","volume-title":"National Serosurvey of Vaccine Preventable Diseases","author":"Robert","year":"2009"},{"key":"S0950268812002130_ref30","unstructured":"WHO. Immunological basis for immunization: mumps (2010) (http:\/\/whqlibdoc.who.int\/publications\/2010\/9789241500661_eng.pdf). Accessed 18 May 2012."},{"key":"S0950268812002130_ref13","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1927.10502953"},{"key":"S0950268812002130_ref25","unstructured":"WHO. Resolution WPR\/RC56.R8: measles elimination, hepatitis B control, and poliomyelitis eradication. Manila, World Health Organization, Regional Committee for the Western Pacific, 2005 (http:\/\/www.wpro.who.int\/NR\/rdonlyres\/185AF547-3C1A-4510-96F2-94D4402355E9\/0\/RC56_R08.pdf). 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Resolution WPR\/RC54.R3: expanded programme on immunization: measles and hepatitis B. Manila, World Health Organization, Regional Committee for the Western Pacific, 2003 (http:\/\/www.wpro.who.int\/rcm\/en\/archives\/rc54\/rc_resolutions\/wpr_rc54_r03.htm). Accessed 18 April 2012."},{"key":"S0950268812002130_ref10","first-page":"1","article-title":"Serosurveillance of rubella in Singapore","volume":"27","year":"2001","journal-title":"Epidemiological News Bulletin"},{"key":"S0950268812002130_ref15","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a036121"},{"key":"S0950268812002130_ref21","first-page":"10","article-title":"Prevalence of antibodies to measles in Singapore","volume":"26","year":"2000","journal-title":"Epidemiological News Bulletin"},{"key":"S0950268812002130_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.05.019"},{"key":"S0950268812002130_ref23","unstructured":"WHO. 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