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Infect."],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>We compared serotype distributions of<jats:italic>Streptococcus pneumoniae<\/jats:italic>isolates from patients aged &lt;5 and \u2a7e5 years with invasive pneumococcal disease in New South Wales, Australia, and antibiotic susceptibilities of isolates from the &lt;5 years age group only, before (2002\u20132004) and after (2005\u20132009) introduction of the 7-valent pneumococcal conjugate vaccine (PCV7). Overall, there were significant decreases in the mean annual number of referred isolates (770<jats:italic>vs<\/jats:italic>. 515) and the proportion belonging to PCV7 serotypes (74%<jats:italic>vs<\/jats:italic>. 38%), but non-PCV7 serotypes, particularly 19A, increased (5%<jats:italic>vs<\/jats:italic>. 18%). All changes were more marked in the &lt;5 years age group. Susceptibility testing of isolates from the &lt;5 years age group showed variation in resistance between serotypes, but significant overall increases in penicillin non-susceptibility (23%<jats:italic>vs<\/jats:italic>. 31%), ceftriaxone resistance (2%<jats:italic>vs<\/jats:italic>. 12%) and multidrug resistance (4%<jats:italic>vs<\/jats:italic>. 7%) rates; erythromycin resistance fell (32%<jats:italic>vs<\/jats:italic>. 25%). Continued surveillance is needed to monitor changes following the introduction of 13-valent PCV in 2012.<\/jats:p>","DOI":"10.1017\/s095026881200218x","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T22:46:14Z","timestamp":1348613174000},"page":"1797-1806","source":"Crossref","is-referenced-by-count":8,"title":["Laboratory surveillance of invasive pneumococcal disease in New South Wales, Australia, before and after introduction of 7-valent conjugate vaccine: reduced disease, but not antibiotic resistance rates"],"prefix":"10.1017","volume":"141","author":[{"given":"S.","family":"OFTADEH","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. F.","family":"GIDDING","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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