{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:40:24Z","timestamp":1762004424754},"reference-count":37,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T00:00:00Z","timestamp":1350345600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>We investigated the genetic structure of 99 isolates of serotype 23F<jats:italic>Streptococcus pneumoniae<\/jats:italic>from children with acute respiratory infections collected over two periods from 1997 to 2006, and 2010. All isolates were susceptible to vancomycin and amoxicillin\u2013clavulanic acid; 97 were resistant to erythromycin, 95 of which carried the<jats:italic>ermB<\/jats:italic>gene and two carried both<jats:italic>mefA\/E<\/jats:italic>and<jats:italic>ermB<\/jats:italic>genes. Multidrug resistance to three or more classes of antibiotics was exhibited by 90 isolates. Sequence types ST342 and ST81 were the most frequent in 1997\u20132006 and 2010, respectively. All CC81 isolates were non-susceptible to \u03b2-lactam antibiotics and had higher minimum inhibitory concentration values for penicillin than other clone complexes and sequence types. The increased \u03b2-lactam antibiotic resistance may have resulted from the replacement of multidrug-resistant clones related to ST81. Long-term studies on<jats:italic>S. pneumoniae<\/jats:italic>serotype 23F, especially the ST81 clone, should be conducted to better understand the epidemiological picture of this pathogen in China.<\/jats:p>","DOI":"10.1017\/s0950268812002269","type":"journal-article","created":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T09:12:30Z","timestamp":1350378750000},"page":"1690-1696","source":"Crossref","is-referenced-by-count":14,"title":["Genotype replacement within serotype 23F<i>Streptococcus pneumoniae<\/i>in Beijing, China: characterization of serotype 23F"],"prefix":"10.1017","volume":"141","author":[{"given":"X.","family":"MA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. H.","family":"YAO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"YU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"ZHOU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q. H.","family":"LI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"SHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M.","family":"HE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. H.","family":"YANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2012,10,16]]},"reference":[{"key":"S0950268812002269_ref37","doi-asserted-by":"publisher","DOI":"10.1086\/422156"},{"key":"S0950268812002269_ref36","first-page":"329","article-title":"The phenotype and genotype patterns of erythromycin-resistant Streptococcus pneumoniae [in Chinese]","volume":"3","author":"Zhao","year":"2004","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"S0950268812002269_ref35","first-page":"936","article-title":"Macrolide-resistant Streptococcus pneumoniae in the pediatric population in Beijing [in Chinese]","volume":"2","author":"Yang","year":"2004","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"S0950268812002269_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2011.03.015"},{"key":"S0950268812002269_ref31","first-page":"1769","article-title":"Molecular epidemiology of serotype 19A Streptococcus pneumoniae isolated from children in Beijing, 1997\u20132006","volume":"124","author":"Xue","year":"2011","journal-title":"Chinese Medical Journal"},{"key":"S0950268812002269_ref30","first-page":"7","article-title":"Antibiotic resistance of serogroup 19 Streptococcus pneumoniae isolated from children in Beijing Children's Hospital from 2000 to 2005 [in Chinese]","volume":"31","author":"Gao","year":"2009","journal-title":"Beijing Yixue"},{"key":"S0950268812002269_ref28","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.diagmicrobio.2010.07.008","article-title":"Genetic structure of Streptococcus pneumoniae isolated from children in a tertiary care university hospital, in Korea, 1995 to 2005","volume":"68","author":"Byung","year":"2010","journal-title":"Diagnostic Microbiology and Infectious Disease"},{"key":"S0950268812002269_ref26","doi-asserted-by":"publisher","DOI":"10.1086\/514783"},{"key":"S0950268812002269_ref25","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.1997.3.253"},{"key":"S0950268812002269_ref24","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.4.1522-1525.2002"},{"key":"S0950268812002269_ref22","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.10.2176"},{"key":"S0950268812002269_ref21","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31805cdbeb"},{"key":"S0950268812002269_ref20","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022823"},{"key":"S0950268812002269_ref19","first-page":"1565","article-title":"Study of serotype distribution, antimicrobial resistance patterns and molecular epidemiology in 148 isolates of invasive Streptococcus pneumoniae","volume":"90","author":"Liu","year":"2010","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"S0950268812002269_ref17","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1128\/JCM.31.10.2724-2728.1993","article-title":"DNA fingerprinting of Streptococus pneumoniae strains by pulsed-field gel electrophoresis","volume":"31","author":"Lefevre","year":"1993","journal-title":"Journal of Clinical Microbiology"},{"key":"S0950268812002269_ref15","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1128\/AAC.40.11.2562","article-title":"Detection of erythromycin-resistant determinants by PCR","volume":"40","author":"Sutcliffe","year":"1996","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"S0950268812002269_ref13","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1128\/JCM.37.10.3296-3299.1999","article-title":"Comparison of agar dilution, microdilution, E-test, and disk diffusion methods for testing activity of cefditoren against Streptococcus pneumoniae","volume":"37","author":"Kelly","year":"1999","journal-title":"Journal of Clinical Microbiology"},{"key":"S0950268812002269_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.06.052"},{"key":"S0950268812002269_ref7","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.3.1294-1300.2005"},{"key":"S0950268812002269_ref4","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/164.2.302"},{"key":"S0950268812002269_ref2","doi-asserted-by":"publisher","DOI":"10.1086\/648593"},{"key":"S0950268812002269_ref1","first-page":"93","article-title":"Pneumococcal conjugated vaccine for childhood immunization. WHO position paper","volume":"82","year":"2007","journal-title":"Weekly Epidemiological Record"},{"key":"S0950268812002269_ref33","doi-asserted-by":"publisher","DOI":"10.3201\/eid1402.070807"},{"key":"S0950268812002269_ref29","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1544"},{"key":"S0950268812002269_ref34","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh118"},{"key":"S0950268812002269_ref23","doi-asserted-by":"publisher","DOI":"10.1086\/594125"},{"key":"S0950268812002269_ref3","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/171.4.890"},{"key":"S0950268812002269_ref6","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.9.3491-3497.2004"},{"key":"S0950268812002269_ref18","doi-asserted-by":"publisher","DOI":"10.1086\/650534"},{"key":"S0950268812002269_ref27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02743.x"},{"key":"S0950268812002269_ref8","doi-asserted-by":"publisher","DOI":"10.1126\/science.1198545"},{"key":"S0950268812002269_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.07.137"},{"key":"S0950268812002269_ref16","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-144-11-3049"},{"key":"S0950268812002269_ref5","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.1998.4.325"},{"key":"S0950268812002269_ref14","first-page":"M100","volume-title":"Performance standards for antimicrobial susceptibility testing: 20th informational supplement","year":"2010"},{"key":"S0950268812002269_ref10","first-page":"253","article-title":"Antimicrobial resistance in Streptococcus pneumoniae in Beijing and molecular typing of penicillin-resistant strains [in Chinese]","volume":"79","author":"Wang","year":"1999","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"S0950268812002269_ref9","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.035675-0"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268812002269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T20:18:29Z","timestamp":1594757909000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268812002269\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,16]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0950268812002269"],"URL":"https:\/\/doi.org\/10.1017\/s0950268812002269","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,16]]}}}