{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:39:49Z","timestamp":1790509189907,"version":"4.1.0"},"reference-count":72,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T00:00:00Z","timestamp":1350345600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p><jats:italic>Cryptosporidium<\/jats:italic>is a zoonotic protozoan parasite with public health importance worldwide. The objectives of this study were to (1) conduct a meta-analysis of published literature for oocyst shedding and diarrhoea outcomes, and (2) develop recommendations for standardization of experimental dose\u2013response studies. Results showed that for the outcome of oocyst shedding in faeces, the covariates \u2018experimental species\u2019, \u2018immunosuppression\u2019, \u2018oocyst dose\u2019 and \u2018oocyst dose\u2019\u00a0\u00d7\u00a0\u2018age\u2019 were all significant (<jats:italic>P<\/jats:italic>\u00a0\u2a7d\u00a00\u00b705). This study suggests that exposing mice, piglets, or ruminants, and using immunosuppressed experimental hosts, is more likely to result in oocyst shedding. For the outcome of diarrhoea in experimentally infected animal species, the key covariates \u2018experimental species\u2019, \u2018age\u2019 and \u2018immunosuppression\u2019 were significant (<jats:italic>P<\/jats:italic>\u00a0\u2a7d\u00a00\u00b72). Therefore, based on the results of this meta-analysis, these variables should be carefully reported and considered when designing experimental dose\u2013response studies. Additionally, detection of possible publication bias highlights the need to publish additional studies that convey statistically non-significant as well as significant results in the future.<\/jats:p>","DOI":"10.1017\/s0950268812002294","type":"journal-article","created":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T12:47:32Z","timestamp":1350391652000},"page":"1662-1678","source":"Crossref","is-referenced-by-count":3,"title":["Individual subject meta-analysis of parameters for<i>Cryptosporidium parvum<\/i>shedding and diarrhoea in animal experimental models"],"prefix":"10.1017","volume":"141","author":[{"given":"A. D.","family":"ADELL","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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