{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T10:33:32Z","timestamp":1648722812989},"reference-count":37,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T00:00:00Z","timestamp":1357516800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The main <jats:italic>Neisseria meningitidis<\/jats:italic> adhesion molecules, type IV pili (Tfp) and <jats:italic>Neisseria<\/jats:italic> adhesion A (NadA), play important roles in the pathogenesis of invasive meningococcal disease. PilE is the major Tfp subunit. In this study, the prevalence and genetic diversity of <jats:italic>pilE<\/jats:italic> and <jats:italic>nadA<\/jats:italic> were investigated in the prevalent serogroups and clonal complexes (CC) of <jats:italic>N. meningitidis<\/jats:italic> isolated in China. All serogroup A strains belonging to CC1 and CC5 and all CC11 serogroup W135 strains were clustered into class II PilE clades. All serogroup C and most of serogroup B isolates except CC8 and ST5642 were class I PilE clades. Class II <jats:italic>pilE<\/jats:italic> sequences were highly conserved. All isolates belonging to class I PilE isolates were <jats:italic>nadA<\/jats:italic> negative. However, <jats:italic>nadA<\/jats:italic>-positive strains were exclusively found in CC5 and CC11 isolates (class II PilE). This study showed that PilE and NadA may be related to epidemic or endemic meningococcal disease.<\/jats:p>","DOI":"10.1017\/s0950268812002944","type":"journal-article","created":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T10:03:29Z","timestamp":1357553009000},"page":"2163-2172","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence and genetic diversity of two adhesion-related genes, <i>pilE<\/i> and <i>nadA<\/i>, in <i>Neisseria meningitidis<\/i> in 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