{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:03:57Z","timestamp":1790057037073,"version":"4.0.1"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T00:00:00Z","timestamp":1361404800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>We assessed the impact of<jats:italic>Haemophilus influenzae<\/jats:italic>type b (Hib) vaccination, introduced in France in early 1993, on the incidence of invasive<jats:italic>Haemophilus influenzae<\/jats:italic>(Hi) disease up to 2008. The incidence of Hi meningitis fell from 0\u00b79\/100\u00a0000 in 1991\u20131992 to 0\u00b709\/100\u00a0000 in 1996\u20132008, with a marked decline (96%) in children aged &lt;5 years, including infants aged &lt;3 months, from 12 to 0\u00b74\/100\u00a0000. The incidence of invasive Hi disease also decreased in children aged &lt;15 years from 6 to 0\u00b77\/100\u00a0000, remained stable in the 15\u201364 years age group at about 0\u00b75\/100\u00a0000, and increased slightly from 2\u00b70 to 2\u00b74\/100\u00a0000 in persons aged &gt;64 years. No emergence of non-encapsulated or encapsulated non-vaccine serotypes was observed. These findings confirm the major direct impact of Hib vaccination on the incidence of Hi invasive disease in children and the indirect benefit of vaccination for infants too young to be vaccinated.<\/jats:p>","DOI":"10.1017\/s0950268813000083","type":"journal-article","created":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T13:59:37Z","timestamp":1361455177000},"page":"1787-1796","source":"Crossref","is-referenced-by-count":22,"title":["Impact of<i>Haemophilus influenzae<\/i>type b vaccination on the incidence of invasive<i>Haemophilus influenzae<\/i>disease in France, 15 years after its introduction"],"prefix":"10.1017","volume":"141","author":[{"given":"S.","family":"GEORGES","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"LEPOUTRE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"DABERNAT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"LEVY-BRUHL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2013,2,21]]},"reference":[{"key":"S0950268813000083_ref29","doi-asserted-by":"publisher","DOI":"10.2807\/esm.02.10.00151-en"},{"key":"S0950268813000083_ref27","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.2.807-810.2004"},{"key":"S0950268813000083_ref26","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268807009168"},{"key":"S0950268813000083_ref22","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.4.1664-1672.2003"},{"key":"S0950268813000083_ref21","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.329.7467.655"},{"key":"S0950268813000083_ref17","doi-asserted-by":"publisher","DOI":"10.1136\/adc.86.6.396"},{"key":"S0950268813000083_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2011.11.027"},{"key":"S0950268813000083_ref31","unstructured":"Perrocheau A . Surveillance of meningococcal invasive infections in France in 2000. Quantitative evaluation through the 3 sources capture-recapture method. Report of the Institut de veille sanitaire, 2006 (http:\/\/www.invs.sante.fr\/publications\/)."},{"key":"S0950268813000083_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.03.024"},{"key":"S0950268813000083_ref13","unstructured":"Fonteneau L , Guthmann JP , Levy-Bruhl D . Estimations of vaccination coverage at 24 months of age through the health certificates \u2013 2004\u20132007. Report of the Institut de veille sanitaire, 2010 (http:\/\/www.invs.sante.fr\/publications\/)."},{"key":"S0950268813000083_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2005.02.005"},{"key":"S0950268813000083_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0399-077X(96)80100-4"},{"key":"S0950268813000083_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0399-077X(00)80027-X"},{"key":"S0950268813000083_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S1773-035X(08)74866-4"},{"key":"S0950268813000083_ref6","first-page":"77","article-title":"Vaccination against Haemophilus influenzae type b. Recommendations of the Technical Committee on Immunization","volume":"18","author":"Roure","year":"1992","journal-title":"Bulletin Epidemiologique Hebdomadaire"},{"key":"S0950268813000083_ref3","first-page":"1","article-title":"The immunization schedule","volume":"1","year":"1993","journal-title":"Bulletin Epidemiologique Hebdomadaire"},{"key":"S0950268813000083_ref32","unstructured":"Berger F , Surveillance of meningococcal invasive infections in France in 2005. Quantitative evaluation through the 3 sources capture-recapture method. Report of the Institut de veille sanitaire, 2010 (http:\/\/www.invs.sante.fr\/publications\/)."},{"key":"S0950268813000083_ref23","doi-asserted-by":"publisher","DOI":"10.1086\/511861"},{"key":"S0950268813000083_ref16","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-311X2007000700021"},{"key":"S0950268813000083_ref4","first-page":"1","article-title":"Epidemiology of Haemophilus influenzae b infections in 2 French districts","volume":"1","author":"Boucher","year":"1992","journal-title":"Bulletin Epidemiologique Hebdomadaire"},{"key":"S0950268813000083_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92117-X"},{"key":"S0950268813000083_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0399-077X(98)80134-0"},{"key":"S0950268813000083_ref18","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199809001-00008"},{"key":"S0950268813000083_ref24","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/164.5.982"},{"key":"S0950268813000083_ref8","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1128\/JCM.32.10.2382-2386.1994","article-title":"PCR for capsular typing of Haemophilus influenzae","volume":"32","author":"Falla","year":"1994","journal-title":"Journal of Clinical Microbiology"},{"key":"S0950268813000083_ref5","first-page":"31","article-title":"Haemophilus influenzae, b serotype and the others","volume":"7","author":"Dabernat","year":"1994","journal-title":"Bulletin Epidemiologique Hebdomadaire"},{"key":"S0950268813000083_ref19","doi-asserted-by":"publisher","DOI":"10.3201\/eid1603.090290"},{"key":"S0950268813000083_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(08)70078-1"},{"key":"S0950268813000083_ref33","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199809001-00007"},{"key":"S0950268813000083_ref28","doi-asserted-by":"publisher","DOI":"10.1086\/345863"},{"key":"S0950268813000083_ref20","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/171.1.93"},{"key":"S0950268813000083_ref30","unstructured":"Perrocheau A . Evaluation of meningococcal infections surveillance in 1996 through the capture-recapture method. 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