{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T10:21:23Z","timestamp":1768472483644,"version":"3.49.0"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2013,8,7]],"date-time":"2013-08-07T00:00:00Z","timestamp":1375833600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Two outbreaks of<jats:italic>Leptospira borgpetersenii<\/jats:italic>serovar Hardjo infection in dairy cattle herds were managed through the application of enhanced biosecurity measures, whole-herd antibiotic treatment and vaccination. Micro-agglutination test antibody titres were determined in paired serum samples at 3 weeks (T<jats:sub>1<\/jats:sub>:<jats:italic>n<\/jats:italic>\u00a0=\u00a0125, 97% seropositivity, median 800, range 100\u201312\u00a0800) and 24 weeks (T<jats:sub>2<\/jats:sub>:<jats:italic>n<\/jats:italic>\u00a0=\u00a0110, 88% seropositivity, median 200, range 100\u20136400) after vaccination and studied in relation to cows' age, herd of origin and sampling time. From T<jats:sub>1<\/jats:sub>to T<jats:sub>2<\/jats:sub>, vaccine-elicited antibody titres decreased by 84\u00b77% (95% CI 76\u00b72\u201390\u00b71). Consistent with increasing immunocompetence in calves (aged &lt;12 months) and immunosenescence in adult cows (aged &gt;36 months) associated with ageing, antibody titres correlated positively with calves' age and negatively with adult cows' age. No cow had cultivable, (histo)pathologically detectable and\/or PCR-detectable leptospires in urine or kidney samples after treatment and vaccination. Vaccination together with proper biosecurity measures and chemoprophylaxis are an affordable insurance to control bovine leptospirosis.<\/jats:p>","DOI":"10.1017\/s0950268813001817","type":"journal-article","created":{"date-parts":[[2013,8,7]],"date-time":"2013-08-07T07:42:34Z","timestamp":1375861354000},"page":"1172-1181","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":56,"title":["Application of an integrated outbreak management plan for the control of leptospirosis in dairy cattle herds"],"prefix":"10.1017","volume":"142","author":[{"given":"L.","family":"MUGHINI-GRAS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"BONFANTI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"NATALE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"COMIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"FERRONATO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"LA GRECA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"PATREGNANI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"LUCCHESE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"MARANGON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2013,8,7]]},"reference":[{"key":"S0950268813001817_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1135(91)90070-V"},{"key":"S0950268813001817_ref11","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007658607963"},{"key":"S0950268813001817_ref24","first-page":"619","article-title":"Leptospirosis in beef herds from western Canada: serum antibody titers and vaccination practices","volume":"52","author":"Van De Weyer","year":"2011","journal-title":"Canadian Veterinary Journal"},{"key":"S0950268813001817_ref9","unstructured":"Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe). 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